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A chemokine-driven positive feedback loop organizes lymphoid follicles
TLDR
It is established that B-lymphocyte chemoattractant (BLC/BCA1) and its receptor, CXCR5, are needed for B-cell homing to follicles in lymph nodes as well as in spleen, and that BLC is required for the development of most lymph nodes and Peyer's patches.
BAFF AND APRIL: a tutorial on B cell survival.
TLDR
The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.
BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
TLDR
BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival and is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAff-deficient mice.
BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth
TLDR
A novel member of the T NF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells is described, suggesting that BAFF plays an important role as costimulator of B cell proliferation and function.
Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations
TLDR
Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti–DNA autoantibodies, and immunoglobulin deposition in the kidneys.
TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family That Weakly Induces Apoptosis*
TLDR
A new ligand in the tumor necrosis factor family is described, designated TWEAK, which resembles many other TNF ligands in the capacity to induce cell death; however, the fact that TWEak-sensitive cells are relatively rare suggests that T WEAK along with lymphotoxins α/β and possibly CD30L trigger death via a weaker, nondeath domain-dependent mechanism.
BAFF: A fundamental survival factor for B cells
TLDR
The elucidation of the role of BAFF has set the stage for a new approach to the treatment of autoimmune disease.
Baff Mediates Survival of Peripheral Immature B Lymphocytes
TLDR
A model in which excessive BAFF-mediated survival of peripheral immature B cells contributes to the emergence and maturation of autoreactive B cells, skewed towards the MZ compartment is supported, providing new clues on mechanisms regulating B cell maturation and tolerance.
Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
TLDR
It is described how interferon-α can induce specific degradation of the nuclear viral DNA without hepatotoxicity and proposed lymphotoxin-β receptor activation as a therapeutic alternative and the development of new therapeutics that, in combination with existing antivirals, may cure hepatitis B.
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