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ziprasidone

Known as: 5-(2-(4-(3-benzisothiazolyl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one, ziprasidone [Chemical/Ingredient], Ziprasidonum 
A benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone functions as an antagonist… 
National Institutes of Health

Related topics

Related topics

26 relations
Adrenergic alpha-Antagonists [MoA]Congestive heart failureDrug AllergyGilles de la Tourette syndrome

Broader (6)

Antipsychotic AgentsDopamine AntagonistsPiperazinesSerotonin Antagonists

Narrower (3)

CP 88059Geodonziprasidone hydrochloride, monohydrate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Validation of LC-TOF-MS screening for drugs, metabolites, and collateral compounds in forensic toxicology specimens.
Liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS) analysis provides an expansive technique for identifying many… 
Highly Cited
2011
Highly Cited
2011
Efficacy and safety of adjunctive oral ziprasidone for acute treatment of depression in patients with bipolar I disorder: a randomized, double-blind, placebo-controlled trial.
OBJECTIVE To assess efficacy and safety of adjunctive ziprasidone in subjects with bipolar depression treated with lithium… 
Highly Cited
2008
Highly Cited
2008
Improvement of phencyclidine-induced social behaviour deficits in rats: Involvement of 5-HT1A receptors
Highly Cited
2008
Highly Cited
2008
Long-Term Changes in Weight and Plasma Lipids during Maintenance Treatment with Ziprasidone
To measure the long-term changes in weight and plasma lipids after switching antipsychotic treatment to ziprasidone, three 52… 
Highly Cited
2007
Highly Cited
2007
5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus
Highly Cited
2006
Highly Cited
2006
Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase.
Highly Cited
2006
Highly Cited
2006
The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down…
Mechanisms of lethality of the three-substituted indolinone and putatively selective cyclin-dependent kinase (CDK)2 inhibitor 3… 
Highly Cited
2004
Highly Cited
2004
Efficacy and tolerability of ziprasidone versus risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder: an 8-week, double-blind, multicenter trial.
BACKGROUND More head-to-head comparisons of antipsychotics are needed to discern the relative efficacy and safety profiles of… 
Highly Cited
2004
Highly Cited
2004
Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle
Calcium activated K+ channels (KCa channels) are found in a variety of smooth muscle tissues, the most characterized of which are… 
Review
1999
Review
1999
Mechanisms of typical and atypical antipsychotic drug action in relation to dopamine and NMDA receptor hypofunction hypotheses of schizophrenia
Available evidence indicates that clozapine is the most effective antipsychotic currently used for the pharmacotherapy of… 
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