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Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire.
TLDR
The Mood Disorder Questionnaire is a useful screening instrument for bipolar spectrum disorder in a psychiatric outpatient population and has good sensitivity and very good specificity. Expand
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
TLDR
The results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder and found further support for the previously reported CACNA1C. Expand
Long-Term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
TLDR
Very early or early onset of bipolar disorder might herald a more severe disease course in terms of chronicity and comorbidity and whether early intervention might modify this risk merits further investigation. Expand
Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression.
TLDR
Olanzapine is more effective than placebo, and combined olanzapine-fluoxetine isMore effective than olanZapine and placebo in the treatment of bipolar I depression without increased risk of developing manic symptoms. Expand
Whole-genome association study of bipolar disorder
TLDR
A comparison of the strongest associations with the genome-wide scan of 1868 patients with BP disorder and 2938 controls who completed the scan as part of the Wellcome Trust Case–Control Consortium indicates concordant signals for SNPs within the voltage-dependent calcium channel, L-type, alpha 1C subunit (CACNA1C) gene. Expand
Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).
TLDR
An independent association of comorbid anxiety with greater severity and impairment in bipolar disorder patients was demonstrated, highlighting the need for greater clinical attention to anxiety in this population, particularly for enhanced clinical monitoring of suicidality. Expand
Effectiveness of adjunctive antidepressant treatment for bipolar depression.
TLDR
The use of adjunctive, standard antidepressant medication, as compared with the use of mood stabilizers, was not associated with increased efficacy or with increased risk of treatment-emergent affective switch. Expand
Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)
TLDR
The methodology used for the selection and certification of the clinical treatment centers, training study personnel, the general approach to clinical management, and the sequential treatment strategies offered in the STEP-BD standard and randomized care pathways for bipolar depression and relapse prevention are reviewed. Expand
Double-blind, placebo-controlled comparison of imipramine and paroxetine in the treatment of bipolar depression.
TLDR
Antidepressants may not be useful adjunctive therapy for bipolar depressed patients with high serum lithium levels or who have symptoms that are refractory to the antidepressant effects of lithium, but both paroxetine and imipramine were superior to placebo for patients with low serum lithium Levels. Expand
A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder.
TLDR
Both lamotrigine and lithium were superior to placebo for the prevention of relapse or recurrence of mood episodes in patients with bipolar I disorder who had recently experienced a manic or hypomanic episode. Expand
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