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The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: schizophrenia trial design and protocol development.
The National Institute of Mental Health initiated the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) program to evaluate the effectiveness of antipsychotic drugs in typicalExpand
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Polydipsia and water intoxication in psychiatric patients: A review of the epidemiological literature
Polydipsia among chronic psychiatric patients is poorly understood and underdiagnosed. It may have three stages: simple polydipsia, polydipsia with water intoxication, and physical complications.Expand
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A double-blind study of paliperidone palmitate and risperidone long-acting injectable in adults with schizophrenia
This 13-week double-blind study was designed to assess noninferiority of the recently approved (in the U.S.) injectable atypical antipsychotic paliperidone palmitate (PP) versus risperidoneExpand
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Schizophrenia and smoking: an epidemiological survey in a state hospital.
OBJECTIVE The authors sought to determine whether smoking is related to schizophrenia or neuroleptic treatment. METHOD Cigarette smoking was measured in all patients hospitalized at a stateExpand
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Randomized, controlled, double-blind multicenter comparison of the efficacy and tolerability of ziprasidone and olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder.
OBJECTIVE Limited randomized, controlled trial data exist on possible differences between atypical antipsychotics in efficacy, overall tolerability, and important indices of health status. TheExpand
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Family management in the prevention of morbidity of schizophrenia. Clinical outcome of a two-year longitudinal study.
Environmental stress may contribute to the clinical morbidity of established cases of schizophrenia treated with optimal neuroleptic drugs. A family-based approach that aimed to enhance theExpand
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Relapse and rehospitalization during maintenance treatment of schizophrenia. The effects of dose reduction and family treatment.
BACKGROUND Previous studies have examined dose reduction and family treatment in schizophrenia, but none has examined their interaction. This study assessed the impact of dose reduction ofExpand
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Effectiveness of switching to ziprasidone for stable but symptomatic outpatients with schizophrenia.
BACKGROUND Many outpatients with schizophrenia experience persistent symptoms or side effects on their current antipsychotic regimen. Few studies have prospectively examined the effects of the priorExpand
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Neuroendocrine Factors Influencing Polydipsia in Psychiatric Patients: An Hypothesis
Polydipsia and water intoxication cause considerable morbidity and mortality in chronic psychiatric patients. The pathophysiology of the disorder is unknown, and there is no effective treatment.Expand
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Polydipsia and water intoxication in a long-term psychiatric hospital
This cross-sectional survey attempts to establish the prevalence of polydipsia and water intoxication at a state hospital (N = 360) using staff diagnosis, specific gravity of the urine (SPGU), weightExpand
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