unc-78 protein, C elegans

To mitigate the deleterious effects of temperature increases on cellular organization and proteotoxicity, organisms have… Expand

We have generated a single-copy knock-in loci for defined gene expression (SKI LODGE) system to insert any DNA by CRISPR/Cas9 at… Expand

Sirtuins are NAD⁺-dependent deacetylases, lipoamidases, and ADP-ribosyltransferases that link cellular metabolism to multiple… Expand

Mechanotransduction in Caenorhabditis elegans touch receptor neurons is mediated by an ion channel formed by MEC-4, MEC-10, and… Expand

It is unclear whether mutations in fused in sarcoma (FUS) cause familial amyotrophic lateral sclerosis via a loss-of-function… Expand

To Silence or Not to Silence Repressed genes commonly have methylated DNA, and/or covalent histone modifications associated with… Expand

We present an optogenetic illumination system capable of real-time light delivery with high spatial resolution to specified… Expand

Overexpression of human alpha-synuclein in model systems, including cultured neurons, drosophila and mice, leads to biochemical… Expand

Kindler syndrome is an autosomal recessive disorder characterized by neonatal blistering, sun sensitivity, atrophy, abnormal… Expand

The genetic control of neuronal differentiation has been studied by examining mutations that affect the development and function… Expand