Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems
- P. Phillips
- BiologyNature reviews genetics
- 1 November 2008
There is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner with the advent of high-throughput functional genomics.
HIERARCHICAL COMPARISON OF GENETIC VARIANCE‐COVARIANCE MATRICES. I. USING THE FLURY HIERARCHY
Flury (1988) has provided an approach to matrix comparison in which a variety of hypotheses are tested, including the two extreme hypotheses prevalent in the evolutionary literature, which are adapted to the problem of comparing G‐matrices by using randomization testing to account for nonindependence induced by family structure.
Comparative quantitative genetics : evolution of the G matrix
VISUALIZING MULTIVARIATE SELECTION
It is concluded that selection may be more usefully classified into two general modes, directional and non linear selection, with stabilizing and disruptive selection as special cases of nonlinear selection.
Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations.
- W. Cresko, A. Amores, J. Postlethwait
- BiologyProceedings of the National Academy of Sciences…
- 20 April 2004
Rapid and repeated armor loss in Alaskan stickleback populations appears to be occurring through the fixation of large-effect variants in the same genes, implicating the same Mendelian armor reduction genes.
Network thinking in ecology and evolution.
Genotype to Phenotype: A Complex Problem
A genome-wide comparison of deletion mutant phenotypes identified a subset of genes that were conditionally essential by strain, including 44 essential genes unique to Σ1278b and 13 unique to reference strain S288c.
Exploring the evolution of environmental sex determination, especially in reptiles
The latest empirical findings in lizards and turtles, as well as promising experimental results from a model organism, that portend an exciting future of progress in finally elucidating the evolutionary cause(s) and significance of TSD.
MULTIPLE FITNESS PEAKS AND EPISTASIS
The evidence that genetic interaction is a common phenomenon in natural populations is reviewed to give strong circumstantial evidence for multiple fitness peaks, although the mapping of epistatic interactions onto fitness surfaces remains incompletely explored.
GENETIC VARIATION FOR OUTCROSSING AMONG CAENORHABDITIS ELEGANS ISOLATES
- H. Teotónio, Diogo Manoel, P. Phillips
- BiologyEvolution; international journal of organic…
- 1 June 2006
The extent of genetic variation for characters directly related to outcrossing, such as male frequency, male mating ability, and male reproductive success, in several wild isolates of the nematode Caenorhabditis elegans is determined.