• Publications
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Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems
  • P. Phillips
  • Biology, Medicine
  • Nature Reviews Genetics
  • 1 November 2008
TLDR
There is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner with the advent of high-throughput functional genomics. Expand
Comparative quantitative genetics : evolution of the G matrix
TLDR
It is proposed that a new field, comparative quantitative genetics, has emerged and the strengths and weaknesses of the many statistical and conceptual approaches now being employed are compared. Expand
HIERARCHICAL COMPARISON OF GENETIC VARIANCE‐COVARIANCE MATRICES. I. USING THE FLURY HIERARCHY
TLDR
Flury (1988) has provided an approach to matrix comparison in which a variety of hypotheses are tested, including the two extreme hypotheses prevalent in the evolutionary literature, which are adapted to the problem of comparing G‐matrices by using randomization testing to account for nonindependence induced by family structure. Expand
VISUALIZING MULTIVARIATE SELECTION
TLDR
It is concluded that selection may be more usefully classified into two general modes, directional and non linear selection, with stabilizing and disruptive selection as special cases of nonlinear selection. Expand
Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations.
TLDR
Rapid and repeated armor loss in Alaskan stickleback populations appears to be occurring through the fixation of large-effect variants in the same genes, implicating the same Mendelian armor reduction genes. Expand
Network thinking in ecology and evolution.
TLDR
Recent applications of network thinking to the evolution of networks at the gene and protein level and to the dynamics and stability of communities are reviewed. Expand
Genotype to Phenotype: A Complex Problem
TLDR
A genome-wide comparison of deletion mutant phenotypes identified a subset of genes that were conditionally essential by strain, including 44 essential genes unique to Σ1278b and 13 unique to reference strain S288c. Expand
HIERARCHICAL COMPARISON OF GENETIC VARIANCE‐COVARIANCE MATRICES. II COASTAL‐INLAND DIVERGENCE IN THE GARTER SNAKE, THAMNOPHIS ELEGANS
TLDR
It is proposed that a conserved pattern of multivariate stabilizing selection may have contributed to conservation of G‐ and E‐matrix structure during the divergence of these populations of gaiter snakes. Expand
Exploring the evolution of environmental sex determination, especially in reptiles
TLDR
The latest empirical findings in lizards and turtles, as well as promising experimental results from a model organism, that portend an exciting future of progress in finally elucidating the evolutionary cause(s) and significance of TSD. Expand
Mutation load and rapid adaptation favour outcrossing over self-fertilization
TLDR
It is shown that outcrossing is favoured in populations of Caenorhabditis elegans subject to experimental evolution both under conditions of increased mutation rate and during adaptation to a novel environment. Expand
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