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The evolutionary fate and consequences of duplicate genes.
Although duplicate genes may only rarely evolve new functions, the stochastic silencing of such genes may play a significant role in the passive origin of new species. Expand
Analysis of population genetic structure with RAPD markers
  • M. Lynch, B. G. MILLIGAN
  • Biology, Medicine
  • Molecular ecology
  • 1 April 1994
Estimators for several population‐genetic parameters (gene and genotype frequencies, within‐ and between‐population heterozygosities, degree of inbreeding and population subdivision, and degree of individual relatedness) are presented along with expressions for their sampling variances. Expand
Preservation of duplicate genes by complementary, degenerative mutations.
Focusing on the regulatory complexity of eukaryotic genes, it is shown how complementary degenerative mutations in different regulatory elements of duplicated genes can facilitate the preservation of both duplicates, thereby increasing long-term opportunities for the evolution of new gene functions. Expand
Estimation of pairwise relatedness with molecular markers.
Two examples are given in which the new estimators are applied to natural populations, one that reveals isolation-by-distance in an annual plant and the other that suggests a genetic basis for a coat color polymorphism in bears. Expand
The Rate and Molecular Spectrum of Spontaneous Mutations in Arabidopsis thaliana
This work searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations, and identified and validated 99 base substitutions and 17 small and large insertions and deletions. Expand
A genome-wide view of the spectrum of spontaneous mutations in yeast
The use of complete-genome sequencing in the characterization of spontaneously arising mutations in the yeast Saccharomyces cerevisiae yields numerous unexpected findings, in particular a very high rate of point mutation and skewed distribution of base-substitution types in the mitochondrion and segmental duplication and deletion in the nuclear genome. Expand
Genetics and Analysis of Quantitative Traits
This book discusses the genetic Basis of Quantitative Variation, Properties of Distributions, Covariance, Regression, and Correlation, and Properties of Single Loci, and Sources of Genetic Variation for Multilocus Traits. Expand
Evolution of the mutation rate.
  • M. Lynch
  • Biology, Medicine
  • Trends in genetics : TIG
  • 1 August 2010
Support is presented for the hypothesis that natural selection pushes mutation rates down to a lower limit set by the power of random genetic drift rather than by intrinsic physiological limitations, and that this has resulted in reduced levels of replication, transcription, and translation fidelity in eukaryotes relative to prokaryotes. Expand
The analysis of population survey data on DNA sequence variation.
Application of the technique to existing studies on mitochondrial DNA in several animal species and on several nuclear genes in Drosophila indicates that the standard errors of genetic diversity estimates are usually quite large, so comparative studies of nucleotide diversity need to be substantially larger than the current standards. Expand
The Ecoresponsive Genome of Daphnia pulex
The Daphnia genome reveals a multitude of genes and shows adaptation through gene family expansions, and the coexpansion of gene families interacting within metabolic pathways suggests that the maintenance of duplicated genes is not random. Expand