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udenafil
Known as:
3-(1-methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-{2-[(2RS)-1-methylpyrrolidin-2-yl]ethyl}-4-propoxybenzenesulfonamide
, 5-(2-propyloxy-5-(1-methyl-2-pyrollidinylethylamidosulfonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo (4,3-d) pyrimidine-7-one
, Benzenesulfonamide, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-propoxy-
A benzenesulfonamide derivative with vasodilatory activity. Udenafil selectively inhibits phosphodiesterase type 5 (PDE5), thus inhibiting the…
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National Institutes of Health
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Related topics
Related topics
5 relations
Narrower (2)
DA-8159
Zydena
Broader (3)
Phosphodiesterase 5 inhibitor
Pyrimidines
Sulfonamides
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
A therapeutic confirmatory study to assess the safety and efficacy of Zydena (udenafil) for the treatment of erectile dysfunction in male patients with diabetes mellitus.
D. Moon
,
D. Yang
,
+5 authors
Je Jong Kim
Journal of Sexual Medicine
2011
Corpus ID: 24497157
INTRODUCTION Patients with diabetes mellitus (DM) are reported to experience more severe erectile dysfunction (ED) symptoms and…
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2011
2011
Chronic administration of udenafil, a selective phosphodiesterase type 5 inhibitor, promotes erectile function recovery in an animal model of bilateral cavernous nerve crush injury.
Chan-Ho Lee
,
H. Kim
,
+4 authors
D. Yang
Journal of Sexual Medicine
2011
Corpus ID: 205896457
INTRODUCTION Preservation of the cavernous nerves (CNs) during radical prostatectomy is crucial for the patient's erectile…
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2010
2010
The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors…
S. L. Cheong
,
A. Dolzhenko
,
+8 authors
G. Pastorin
Journal of Medicinal Chemistry
2010
Corpus ID: 39951915
Among the heterocyclic structures identified as potent human A(3) (hA(3)) adenosine receptor's antagonists, we have demonstrated…
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2009
2009
Safety and efficacy of the simultaneous administration of udenafil and an α-blocker in men with erectile dysfunction concomitant with BPH/LUTS
B. Chung
,
Jeong-Deuk Lee
,
Seung Hwan Lee
,
S. Yoo
,
Suhyuk Lee
,
C. Oh
International journal of impotence research
2009
Corpus ID: 23834592
We evaluated the clinical efficacy and safety of administering udenafil (5-[2-propyloxy-5-(1-methyl-2…
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2009
2009
YC-1 Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells
Xiao-ming Liu
,
K. Peyton
,
Natalia Mendelev
,
Hong Wang
,
D. Tulis
,
W. Durante
Molecular Pharmacology
2009
Corpus ID: 10882849
The benzylindazole derivative 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) is an allosteric stimulator of soluble…
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2006
2006
Regioselective functionalization of trisubstituted pyridines using a bromine-magnesium exchange.
H. Ren
,
P. Knochel
Chemical Communications
2006
Corpus ID: 7453145
A tosyloxy substituent in position 2 allows a highly regioselective Br/Mg exchange reaction on 3,5-dibromopyridine derivatives…
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Highly Cited
2002
Highly Cited
2002
1H and 13C NMR Study of 1-Hydrazino-2,3-dihydro-1H-pyrazolo[1,2-a]pyridazine-5,8-diones and -1H-pyrazolo[1,2-b]phthalazine-5,10-diones and Their Ring-Chain Tautomerism
J. Sinkkonen
,
V. Ovcharenko
,
+4 authors
K. Pihlaja
2002
Corpus ID: 55134700
Treatment of 1-hydroxy-2,3-dihydro-1H-pyrazolo[1,2-a]pyridazine-5,8-diones and -1H-pyrazolo[1,2-b]phthalazine-5,10-diones with…
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1994
1994
Synthesis and analgesic properties of 5-acyl-arylhydrazone 1-H pyrazolo [3,4-b] pyridine derivatives.
L. Dias
,
M. Alvim
,
A. Freitas
,
E. Barreiro
,
A. Miranda
Pharmaceutica Acta Helvetiae
1994
Corpus ID: 1431046
1990
1990
Antitumor effect of a new organic selenium compound, 6-phenyl-7 (6H)-isoselenazolo [4,3-d] pyrimidone (ISP), on the growth of P388 mouse leukemia.
H. Ito
,
J. Wang
,
K. Shimura
,
J. Sakakibara
,
T. Ueda
Anticancer Research
1990
Corpus ID: 39143011
The organic selenium compound, ISP [6-phenyl-7(6H)-isoselenazolo [4,3-d] pyrimidone] markedly inhibited the growth of P388 mouse…
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1984
1984
Synthesis and antiviral/antitumor activities of certain pyrazolo[3,4-d]pyrimidine-4(5H)-selone nucleosides and related compounds.
B. Ugarkar
,
H. Cottam
,
P. Mckernan
,
R. K. Robins
,
G. R. Revankar
Journal of Medicinal Chemistry
1984
Corpus ID: 25546067
Several pyrazolo[3,4-d]pyrimidine-4(5H)-selone ribonucleosides were prepared as potential antiparasitic agents. Treatment of 4…
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