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DA-8159

Known as: DA 8159 
National Institutes of Health

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udenafil

Papers overview

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2006
2006
Erectile potentials of a new phosphodiesterase type 5 inhibitor, DA-8159, in diet-induced obese rats.
AIM To examine the changes in the erectile function in diet-induced obese rats and investigate the oral efficacy of DA-8159, a… 
2005
2005
Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous DA‐8159, a new erectogenic, in rats
In order to find what types of hepatic microsomal cytochrome P450 (CYP) isozymes are involved in the metabolism of DA‐8159 and in… 
2005
2005
DA-8159 : Erectogenic
Phosphodiesterase type 5 (PDE5) is an important target for the treatment of erectile dysfunction (ED). A novel, orally available… 
2005
2005
Species differences in the formation of DA-8164 after intravenous and/or oral administration of DA-8159, a new erectogenic, to mice, rats, rabbits, dogs and humans.
Species differences in the formation of DA-8164 after intravenous and/or oral administration of DA-8159 to mice, rats, rabbits… 
2004
2004
Role of human cytochrome P450 3A4 in the metabolism of DA–8159, a new erectogenic
  • H. JiH. Lee H. S. Lee
  • Xenobiotica; the fate of foreign compounds in…
  • 2004
  • Corpus ID: 28407946
1. The purpose of this paper was to characterize cytochrome P450 (CYP) enzymes involved in N-dealkylation of a new oral… 
2004
2004
The effect of DA-8159 on corpus cavernosal smooth muscle relaxation and penile erection in diabetic rabbits
A previous study showed that DA-8159, a potent type 5 phosphodiesterase inhibitor, enhanced the relaxation of the smooth muscles… 
2003
2003
DA-8159, a New PDE5 Inhibitor, Attenuates the Development of Compensatory Right Ventricular Hypertrophy in a Rat Model of Pulmonary Hypertension
This study evaluated the effect of DA-8159, a new phosphodiesterase 5 inhibitor, on the compensatory development of right… 
2002
2002
In vitro metabolism of a novel phosphodiesterase-5 inhibitor DA-8159 in rat liver preparations using liquid chromatography/electrospray mass spectrometry.
The in vitro metabolism of a new erectogenic, DA-8159, has been studied by LC with UV detection and on-line LC-electrospray mass… 
Highly Cited
2000
Highly Cited
2000
Factors influencing the protein binding of a new phosphodiesterase V inhibitor, DA-8159, using an equilibrium dialysis technique.
Various factors influencing the protein binding of DA-8159 to 4% human serum albumin (HSA) were evaluated using an equilibrium… 
2000
2000
Pharmacokinetics, stability, and blood partition of DA-8159, a new phosphodiesterase V inhibitor.
The pharmacokinetics of DA-8159, a new phosphodiesterase V inhibitor, after 1 min intravenous, 30 mg/kg, and oral, 30 mg/kg… 
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