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Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models
It is suggested that DA-6034 prevents gastric mucosal injury, and these gastroprotective activities appear to be due to the increase in the gastric defensive systems.
Factors influencing the protein binding of a new phosphodiesterase V inhibitor, DA-8159, using an equilibrium dialysis technique.
The binding of DA-8159 in heparinized human plasma (93.9%) was significantly higher than in rats, rabbits, rabbit, and dogs, and this could be due to differences in AAG concentrations in plasma.
Mechanism of erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159
DA-8159 is a selective inhibitor of PDE 5-catalyzed cGMP hydrolysis and the enhancement of a penile erection by DA- 8159 is mediated by the relaxation of the cavernosal smooth muscle by the NO-stimulated cG MP accumulation.
Discovery of DA-1229: a potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.
Simultaneous determination of sildenafil and its active metabolite UK-103,320 in human plasma using liquid chromatography-tandem mass spectrometry.
Determination of a new phosphodiesterase V inhibitor, DA-8159, in plasma and urine by high-performance liquid chromatography.
Role of human cytochrome P450 3A4 in the metabolism of DA–8159, a new erectogenic
- H. Ji, H. W. Lee, H. Lee
- Biology, ChemistryXenobiotica; the fate of foreign compounds in…
- 1 January 2004
There is the possibility of drug-drug interactions when prescribing DA-8159 concomitantly with known inhibitors or inducers of CYP3A4, and drug–drug interactions would not be predicted on the basis of DA- 8159 inhibiting the metabolism of coadministered drugs.
DA-8159 : Erectogenic
A novel, orally available selective inhibitor of PDE5, DA-8159, is under development for the treatment of ED, as it does not inhibit PDE11, which may be related to testicular toxicity and myalgia.
Effect of DA-6034, a derivative of flavonoid, on experimental animal models of inflammatory bowel disease
Oral therapy of DA-6034 attenuated the macroscopic and histologic damages of the colon in all three experimental models of IBD, which suggest that DA- 6034 could be a promising drug in the treatment of I BD.
Erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159
- T. Oh, K. Kang, B. Ahn, M. Yoo, W. B. Kim
- Biology, MedicineArchives of pharmacal research
- 1 October 2000
In pentobarbital-anesthetized dogs, the intravenous administration of DA-8159 potentiated the increase in ICP induced by the intracavernosal SNP in a dose-related manner, suggesting that DA- 8159 has significant therapeutic potential in the treatment of erectile dysfunction.