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Dose‐linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats
Oleanolic acid was metabolically unstable following incubation with rat liver microsomes in the presence of NADPH, and the very low oral bioavailability could be due to a poor absorption and extensive metabolic clearance.
Effects of Eupatilin and Jaceosidin on Cytochrome P450 Enzyme Activities in Human Liver Microsomes
In vitro results suggest that eupatilin and jaceosidin should be further examined for potential pharmacokinetic drug interactions in vivo due to inhibition of CYP1A2 and CYP2C9.
Corydaline Inhibits Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
In vitro results suggest that corydaline should be evaluated for potential pharmacokinetic drug interactions in vivo due to potent inhibition of CYP2C19 and CYP3A-mediated midazolam hydroxylation.
Pharmacokinetics of a ginseng saponin metabolite compound K in rats
The absorption, dose‐linearity and pharmacokinetics of compound K, a major intestinal bacterial metabolite of ginsenosides, were evaluated in vitro and in vivo. Using the Caco‐2 cell monolayers,…
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of levofloxacin in human plasma.
Simultaneous determination of piroxicam, meloxicam and tenoxicam in human plasma by liquid chromatography with tandem mass spectrometry.
Quantification of doxazosin in human plasma using hydrophilic interaction liquid chromatography with tandem mass spectrometry.
Hydrophilic interaction LC with MS/MS (HILIC-MS/MS) was described as a rapid, sensitive, and selective method for the quantification ofDoxazosin in human plasma and successfully applied to the pharmacokinetic study of doxazoin in humans.
Simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic…
A rapid, sensitive and selective liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and…
Simultaneous determination of sildenafil and its active metabolite UK-103,320 in human plasma using liquid chromatography-tandem mass spectrometry.