FAQ

ubiquitin C-terminal hydrolase

Known as: Ubiquitin C Terminal Hydrolase, Ubiquitin Carboxy Terminal Hydrolase, Hydrolase, Ubiquitin C-Terminal 
The Ubiquitin C-Terminal Hydrolases (UCH) are deubiquitinating enzymes which hydrolyze carboxyl-terminal esters and amides of ubiquitin to generate… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1950-2017
020406019502016

Related topics

Related topics

26 relations
BAP1 geneCYLD protein, humanEnzyme GeneHydrolase Gene
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Narrower (5)

BAP1 protein, humanSTAMBP protein, humanUSP6 protein, humanUSP8 protein, human
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
ubiquitin C-terminal hydrolase
Hydrolysis
physiological aspects
chemical synthesis
UCHL1 protein, human
CYLD protein, human

Papers overview

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Highly Cited
2010
Highly Cited
2010
Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury.
OBJECTIVE Ubiquitin C-terminal hydrolase (UCH-L1), also called neuronal-specific protein gene product (PGP 9.3), is highly… (More)
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2010
2010
Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1), also called neuronal-specific protein gene product 9.5, is a highly abundant protein… (More)
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2009
2009
Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is selectively and abundantly expressed in the brain… (More)
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2009
2009
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) catalyses the hydrolysis of ubiquitin ester and amide mainly in neuronal cells… (More)
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2009
2009
Expression and Functional Studies of Ubiquitin C-Terminal Hydrolase L1 Regulated Genes
Deubiquitinating enzymes (DUBs) have been increasingly implicated in regulation of cellular processes, but a functional role for… (More)
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Highly Cited
2003
Highly Cited
2003
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron.
Mammalian neuronal cells abundantly express a deubiquitylating enzyme, ubiquitin carboxy-terminal hydrolase 1 (UCH L1). Mutations… (More)
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Highly Cited
1999
Highly Cited
1999
Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice
The gracile axonal dystrophy (gad) mouse is an autosomal recessive mutant that shows sensory ataxia at an early stage, followed… (More)
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Highly Cited
1999
Highly Cited
1999
Structural basis for the specificity of ubiquitin C-terminal hydrolases.
The release of ubiquitin from attachment to other proteins and adducts is critical for ubiquitin biosynthesis, proteasomal… (More)
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Highly Cited
1998
Highly Cited
1998
Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases.
Ubiquitin C-terminal hydrolases (UCH) are deubiquitinating enzymes which hydrolyze C-terminal esters and amides of ubiquitin… (More)
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Highly Cited
1997
Highly Cited
1997
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
The switch from short-term to long-term facilitation of the synapses between sensory and motor neurons mediating gill and tail… (More)
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