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Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors.
Results demonstrate that superoxide is generated from the oxygenase domain by dissociation of the ferrous-dioxygen complex and that occupation of the L-arginine binding site does not inhibit this process, and indicate that modulation of BH4 concentration may regulate the ratio of superoxide to nitric oxide generated by eNOS. Expand
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.
Although the deleterious vasoconstrictive effects of cell-free, hemoglobin-based blood substitutes have been appreciated, the systemic effects of chronic hemolysis on nitric oxide bioavailabilityExpand
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver.
The results suggest that nitrite is a biological storage reserve of NO subserving a critical function in tissue protection from ischemic injury and an unexpected and novel therapy for diseases such as myocardial infarction, organ preservation and transplantation, and shock states. Expand
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
It is demonstrated here that plasma from patients with sickle-cell disease contains cell-free ferrous hemoglobin, which stoichiometrically consumes micromolar quantities of nitric oxide and abrogates forearm blood flow responses to Nitric oxide donor infusions. Expand
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control.
Hypoxic vasodilation is a fundamental, highly conserved physiological response that requires oxygen and/or pH sensing coupled to vasodilation. While this process was first characterized more than 80Expand
The mechanism of transmembrane S-nitrosothiol transport.
  • Yanhong Zhang, N. Hogg
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 25 May 2004
The effect of cystine on the transfer of the S-nitroso functional group from the extracellular to the intracellular space is assessed, and it is found that the presence of L-cystine enhanced GSNO-dependent S-Nitrosothiol uptake, increasing the intrACEllular S- nitrogenothiol level from approximately 60 pmol/mg of protein to approximately 3 nmol/ mg of protein. Expand
The emerging biology of the nitrite anion
Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis. A recent two-day symposium at the US NationalExpand
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin.
A fundamental heme globin- and Nitrite-catalyzed chemical reaction pathway to N2O3, NO and S-nitrosothiol that could form the basis of in vivo nitrite-dependent signaling is revealed. Expand
The biochemistry and physiology of S-nitrosothiols.
  • N. Hogg
  • Chemistry, Medicine
  • Annual review of pharmacology and toxicology
  • 2002
This review attempts to highlight the gulf between the chemical understanding of S-nitrosothiols and the proposed biological activities of these compounds with respect to guanylyl cyclase-independent nitric oxide bioactivity and also the control of vascular tone. Expand
The chemical biology of S-nitrosothiols.
This review attempts to describe the biological chemistry of S-nitrosation and to point out where the challenges lie in matching the known chemical biology of these compounds with their reported functions. Expand