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tyrphostin 47

Known as: 3,4-dihydroxy-alpha-cyanothiocinnamide, Tyrphostin A47, alpha-cyano-3,4-dihydroxythiocinnamamide 
A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor, capacitative calcium ion entry into… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

AG-213RG 50864

Broader (2)

Enzyme InhibitorsTyrphostins
Receptor Tyrosine Kinase Inhibition

Papers overview

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Highly Cited
2002
Highly Cited
2002
Different signal transduction pathways are involved during human sperm capacitation induced by biological and pharmacological agents.
Human sperm capacitation involves complex signal transduction mechanisms during which double phosphorylation of the threonine… 
2001
2001
Regulation of p42/p44 MAPK and p38 MAPK by the adenosine A(1) receptor in DDT(1)MF-2 cells.
Highly Cited
2000
Highly Cited
2000
Participation of Tyrosine Phosphorylation in Cytoskeletal Reorganization, &agr;IIb&bgr;3 Integrin Receptor Activation, and Aspirin-Insensitive Mechanisms of Thrombin-Stimulated Human Platelets
BackgroundFibrinogen binding to the active conformation of the &agr;IIb&bgr;3 integrin receptor (glycoprotein IIb/IIIa) and… 
Highly Cited
1999
Highly Cited
1999
Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction.
Neuronal cells undergo rapid growth cone collapse, neurite retraction, and cell rounding in response to certain G protein-coupled… 
Highly Cited
1997
Highly Cited
1997
Direct block of voltage-sensitive sodium channels by genistein, a tyrosine kinase inhibitor.
Genistein, an isoflavone inhibitor of tyrosine-specific protein kinases, was shown to specifically block the 22Na+ influx through… 
Highly Cited
1996
Highly Cited
1996
Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats
We compared the effects of the tyrosine kinase inhibitor genistein, a naturally occurring isoflavone, to those of tyrphostin A25… 
Highly Cited
1995
Highly Cited
1995
Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers.
The involvement of tyrosine phosphorylation in the regulation of epithelial cell Cl- secretion is unknown. Therefore, the purpose… 
Highly Cited
1994
Highly Cited
1994
Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.
Studies presented here show that overall NF-kappa B signal transduction begins with a parallel series of stimuli-specific… 
1994
1994
Genistein reduces tumor necrosis factor alpha-induced plasminogen activator inhibitor-1 transcription but not urokinase expression in human endothelial cells.
The plasminogen activator inhibitor PAI-1 is markedly elevated in vivo and in vitro upon exposure to the inflammatory mediators… 
Highly Cited
1993
Highly Cited
1993
Mechanism of lipopolysaccharide-triggered junB activation in a mouse macrophage-like cell line (J774).
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