• Publications
  • Influence
The emerging role of lysophosphatidic acid in cancer
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptorExpand
  • 952
  • 44
Detecting cAMP‐induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator
Epac1 is a guanine nucleotide exchange factor for Rap1 that is activated by direct binding of cAMP. In vitro studies suggest that cAMP relieves the interaction between the regulatory and catalyticExpand
  • 418
  • 35
  • PDF
Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho
Addition of the bioactive phospholipid lysophosphatidic acid (LPA) or a thrombin receptor-activating peptide (TRP) to serum-starved N1E-115 or NG108-15 neuronal cells causes rapid growth coneExpand
  • 621
  • 33
  • PDF
The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein
Gap junctions mediate cell-cell communication in almost all tissues and are composed of channel-forming integral membrane proteins, termed connexins [1-3]. Connexin43 (Cx43) is the most widelyExpand
  • 489
  • 33
Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells
A critical role for the small GTPase Rho and one of its targets, p160ROCK (a Rho-associated coiled coil-forming protein kinase), in neurite remodeling was examined in neuroblastoma N1E-115 cells.Expand
  • 458
  • 27
  • PDF
The ins and outs of lysophosphatidic acid signaling
Lysophosphatidic acid (LPA) is a lipid mediator with a wide variety of biological actions, particularly as an inducer of cell proliferation, migration and survival. LPA binds to specificExpand
  • 506
  • 23
TRPM7, a novel regulator of actomyosin contractility and cell adhesion
Actomyosin contractility regulates various cell biological processes including cytokinesis, adhesion and migration. While in lower eukaryotes, α‐kinases control actomyosin relaxation, a similar roleExpand
  • 295
  • 22
The bioactive phospholipid lysophosphatidic acid is released from activated platelets.
Lysophosphatidic acid (LPA) is a water-soluble phospholipid with hormone-like and growth-factor-like activities. LPA activates a putative G-protein-coupled receptor in responsive cells, but theExpand
  • 623
  • 20
  • PDF
Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger (*)
  • W. Moolenaar
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2 June 1995
  • 568
  • 20
Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development
ABSTRACT Autotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted lysophospholipase D that promotes cell migration, metastasis, and angiogenesis. ATX generatesExpand
  • 466
  • 20
  • PDF