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tumor suppressor protein p73

Known as: p73, Protein, Tumor Protein p73 [Chemical/Ingredient], Protein p73, Tumor 
A homolog of p53 TUMOR SUPPRESSOR PROTEIN that encodes full-length trans-activating and N-terminally-truncated (DeltaN) isoforms. Detection of splice… Expand
National Institutes of Health

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11 relations
In BloodProcess of secretionTP73 geneagonists
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delta Np73 protein, humanp73 protein, human

Papers overview

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Highly Cited
2005
Highly Cited
2005
The ubiquitin–protein ligase Itch regulates p73 stability
p73, a member of the p53 family of transcription factors, is upregulated in response to DNA damage, inducing cell cycle arrest… Expand
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Highly Cited
2002
Highly Cited
2002
Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients
The p73 gene is a p53 homologue which induces apoptosis and inhibits cell proliferation. Although p73 maps at 1p36.3 and is… Expand
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Highly Cited
2001
Highly Cited
2001
C-Terminal Ubiquitination of p53 Contributes to Nuclear Export
ABSTRACT The growth inhibitory functions of p53 are controlled in unstressed cells by rapid degradation of the p53 protein. One… Expand
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Highly Cited
2000
Highly Cited
2000
A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
The p73 protein, a homologue of the tumour-suppressor protein p53, can activate p53-responsive promoters and induce apoptosis in… Expand
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Review
2000
Review
2000
Molecular mechanisms involved in cisplatin cytotoxicity
Abstract.cis-diamminedichloroplatinum(II) or cisplatin is a DNA-damaging agent that is widely used in cancer chemotherapy… Expand
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Highly Cited
2000
Highly Cited
2000
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
Strong stimulation of the T-cell receptor (TCR) on cycling peripheral T cells causes their apoptosis by a process called TCR… Expand
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Highly Cited
2000
Highly Cited
2000
Role of the p53-homologue p73 in E2F1-induced apoptosis
Most human cancers harbour aberrations of cell-cycle control, which result in deregulated activity of the E2F transcription… Expand
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Highly Cited
1999
Highly Cited
1999
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
The protein p73 is a structural and functional homologue of the p53 tumour-suppressor protein but, unlike p53, it is not induced… Expand
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Highly Cited
1999
Highly Cited
1999
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
Cancer chemotherapeutic agents such as cisplatin exert their cytotoxic effect by inducing DNA damage and activating programmed… Expand
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Highly Cited
1999
Highly Cited
1999
Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.
The p73 gene is located on 1p36.2-3, a region that is frequently deleted in human cancer. Because p73 encodes for a protein that… Expand
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