tumor suppressor protein p73

Known as: p73, Protein, Tumor Protein p73 [Chemical/Ingredient], Protein p73, Tumor 
A homolog of p53 TUMOR SUPPRESSOR PROTEIN that encodes full-length trans-activating and N-terminally-truncated (DeltaN) isoforms. Detection of splice… (More)
National Institutes of Health

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In BloodProcess of secretionTP73 geneagonists
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delta Np73 protein, humanp73 protein, human

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Highly Cited
2011
Highly Cited
2011
p73 in Cancer.
p73 is a tumor suppressor belonging to the p53 family of transcription factors. Distinct isoforms are transcribed from the p73… (More)
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Highly Cited
2007
Highly Cited
2007
SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity.
The tumor suppressor p53-related p73 shares significant amino-acid sequence identity with p53. Like p53, p73 recognizes canonical… (More)
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Highly Cited
2005
Highly Cited
2005
The ubiquitin-protein ligase Itch regulates p73 stability.
p73, a member of the p53 family of transcription factors, is upregulated in response to DNA damage, inducing cell cycle arrest… (More)
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Review
2002
Review
2002
Role of p73 in malignancy: tumor suppressor or oncogene?
The recently identified p53 family member, p73, shows substantial structural and functional homology with p53. However, despite… (More)
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Highly Cited
2000
Highly Cited
2000
Role of the p53-homologue p73 in E2F1-induced apoptosis
Most human cancers harbour aberrations of cell-cycle control, which result in deregulated activity of the E2F transcription… (More)
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Highly Cited
2000
Highly Cited
2000
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
Strong stimulation of the T-cell receptor (TCR) on cycling peripheral T cells causes their apoptosis by a process called TCR… (More)
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Highly Cited
1999
Highly Cited
1999
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
Cancer chemotherapeutic agents such as cisplatin exert their cytotoxic effect by inducing DNA damage and activating programmed… (More)
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Highly Cited
1999
Highly Cited
1999
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
The protein p73 is a structural and functional homologue of the p53 tumour-suppressor protein but, unlike p53, it is not induced… (More)
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Highly Cited
1999
Highly Cited
1999
Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.
The p73 gene is located on 1p36.2-3, a region that is frequently deleted in human cancer. Because p73 encodes for a protein that… (More)
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Highly Cited
1999
Highly Cited
1999
Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma.
BACKGROUND The protein p73, the first identified homologue of the tumor suppressor gene p53 (also known as TP53), has been shown… (More)
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