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tumor suppressor protein p73

Known as: p73, Protein, Tumor Protein p73 [Chemical/Ingredient], Protein p73, Tumor 
A homolog of p53 TUMOR SUPPRESSOR PROTEIN that encodes full-length trans-activating and N-terminally-truncated (DeltaN) isoforms. Detection of splice… 
National Institutes of Health

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In BloodProcess of secretionTP73 geneagonists

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delta Np73 protein, humanp73 protein, human

Papers overview

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2010
2010
Securinine induces p73‐dependent apoptosis preferentially in p53‐deficient colon cancer cells
The identification of agents that preferentially kill cancer cells while protecting normal cells offers the potential to overcome… 
Review
2008
Review
2008
iASPP inhibition: increased options in targeting the p53 family for cancer therapy.
Strategies to induce p53 for cancer therapy offer appeal but many tumors harbor inactivating p53 mutations. One way to address… 
Highly Cited
2006
Highly Cited
2006
Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma.
p63 is essential for normal epithelial development and is overexpressed in the vast majority of squamous cell carcinomas (SCC… 
Highly Cited
2005
Highly Cited
2005
Ruthenium (II)-Derived Organometallic Compounds Induce Cytostatic and Cytotoxic Effects on Mammalian Cancer Cell Lines through p53-Dependent and p53-Independent Mechanisms
The metallic compound cisplatin has been used for many years to treat various human cancers. Here, we describe the cytostatic and… 
2005
2005
Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status.
PURPOSE To study the relationship between protein expression and DNA methylation of a triad of cell-cycle regulatory genes known… 
2005
2005
The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73.
p73, a member of the p53 family, is expressed from two separate promoters, generating TA and DeltaN variants. Each variant… 
2002
2002
The Expression of P73, P21 and MDM2 Proteins in Gliomas
Abstractp73 protein, a member of the p53 family protein, induce p21 and MDM2 transcription. In some carcinomas, the expression of… 
Highly Cited
1999
Highly Cited
1999
Distinct Regulation of p53 and p73 Activity by Adenovirus E1A, E1B, and E4orf6 Proteins
ABSTRACT Multiple adenovirus (Ad) early proteins have been shown to inhibit transcription activation by p53 and thereby to alter… 
Highly Cited
1999
Highly Cited
1999
Comparative Analysis of P73 and P53 Regulation and Effector Functions
p53 is mutated in ∼50% of human cancers, whereas mutations of the related p73 gene are rare. p73 can activate p53-responsive… 
1999
1999
Distinct expression patterns of the p53-homologue p73 in malignant and normal hematopoiesis assessed by a novel real-time reverse transcription-polymerase chain reaction assay and protein analysis.
The role of the recently identified first p53-homologue, p73, in neoplastic transformation is unknown. To elucidate p73 gene… 
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