tryptophan catabolic process

Known as: tryptophan breakdown, tryptophan catabolism, tryptophan degradation 
The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. [ISBN… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1948-2017
020406019482016

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tryptophanase activity

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
tryptophan catabolic process
tryptophanase activity

Papers overview

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Highly Cited
2010
Highly Cited
2010
An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells.
The aryl hydrocarbon receptor (AHR) has been known to cause immunosuppression after binding dioxin. It has recently been… (More)
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Highly Cited
2008
Highly Cited
2008
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
Half a century ago, chronic granulomatous disease (CGD) was first described as a disease fatally affecting the ability of… (More)
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Highly Cited
2006
Highly Cited
2006
The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells.
Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby… (More)
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Highly Cited
2004
Highly Cited
2004
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation.
Marrow stromal cells (MSCs) inhibit allogeneic T-cell responses, yet the molecular mechanism mediating this immunosuppressive… (More)
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Highly Cited
2003
Highly Cited
2003
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
T lymphocytes undergo proliferation arrest when exposed to tryptophan shortage, which can be provoked by indoleamine 2,3… (More)
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Highly Cited
2003
Highly Cited
2003
Modulation of tryptophan catabolism by regulatory T cells
Regulatory T (TR) cells manifest constitutive expression of cytotoxic T lymphocyte–associated antigen 4 (CTLA-4), but the… (More)
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Highly Cited
2002
Highly Cited
2002
CTLA-4–Ig regulates tryptophan catabolism in vivo
Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) plays a critical role in peripheral tolerance. However, regulatory pathways… (More)
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Highly Cited
2002
Highly Cited
2002
T cell apoptosis by tryptophan catabolism
Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that, expressed by different cell types, has regulatory… (More)
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Highly Cited
2001
Highly Cited
2001
Increased cortical kynurenate content in schizophrenia.
BACKGROUND Metabolites of the kynurenine pathway of tryptophan degradation may play a role in the pathogenesis of several human… (More)
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Highly Cited
1999
Highly Cited
1999
Inhibition of  T Cell Proliferation by Macrophage Tryptophan Catabolism
We have recently shown that expression of the enzyme indoleamine 2, 3-dioxygenase (IDO) during murine pregnancy is required to… (More)
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