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tryptophan catabolic process

Known as: tryptophan breakdown, tryptophan catabolism, tryptophan degradation 
The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. [ISBN… 
National Institutes of Health

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tryptophanase activity

Papers overview

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Highly Cited
2009
Highly Cited
2009
Nontargeted urinary metabolite profiling of a mouse model of Crohn's disease.
Crohn's disease is an inflammatory disorder of the bowel, believed to arise from the dysregulation of intestinal mucosal immunity… 
Highly Cited
2008
Highly Cited
2008
Differential immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO) on primary human CD4+ and CD8+ T cells
We have previously demonstrated that indoleamine 2,3-dioxygenase (IDO) expression by skin cells generates a tryptophan deficient… 
Review
2006
Review
2006
Toll‐like receptor 9‐mediated induction of the immunosuppressive pathway of tryptophan catabolism
A series of recent studies, including an article in this issue of the European Journal of Immunology, have demonstrated that the… 
Highly Cited
2005
Highly Cited
2005
Tryptophan degradation in patients with gynecological cancer correlates with immune activation.
2005
2005
Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12
DAP12 is an immunoreceptor tyrosine‐based activation motif‐bearing membrane adapter molecule expressed by different cell types… 
Highly Cited
2003
Highly Cited
2003
Longitudinal study of tryptophan degradation during and after pregnancy.
Highly Cited
2003
Highly Cited
2003
Atorvastatin suppresses interferon‐γ‐induced neopterin formation and tryptophan degradation in human peripheral blood mononuclear cells and in monocytic cell lines
Inhibitors of 3‐hydroxy‐3methylglutaryl‐co‐enzyme A (HMG‐CoA) reductase, so‐called statins, are used in medical practice because… 
Highly Cited
2001
Highly Cited
2001
The role of l‐tryptophan transport in l‐tryptophan degradation by indoleamine 2,3‐dioxygenase in human placental explants
1 The physiological importance of l‐tryptophan transport for placental indoleamine 2,3‐dioxygenase‐mediated degradation of l… 
Highly Cited
1999
Highly Cited
1999
Replication of Toxoplasma gondii, but NotTrypanosoma cruzi, Is Regulated in Human Fibroblasts Activated with Gamma Interferon: Requirement of a Functional JAK/STAT Pathway
ABSTRACT To study the role of tryptophan degradation by indoleamine 2,3-dioxygenase (INDO) in the control of Trypanosoma cruzior… 
Highly Cited
1998
Highly Cited
1998
Inhibition of Chlamydia pneumoniae replication in HEp-2 cells by interferon-gamma: role of tryptophan catabolism.
Interferon-gamma (IFN-gamma) induces tryptophan catabolism in HEp-2 cells, possibly via stimulation of host cell indoleamine-2,3… 
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