• Publications
  • Influence
Neopterin as a marker for immune system activation.
TLDR
Neopterin production provides prognostic information in patients with malignant tumor diseases and in HIV-infected individuals, high levels being associated with poorer survival expectations and the extent of oxidative stress can be estimated by neopterin measurements. Expand
HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells.
TLDR
It is shown that IDO mRNA expression is elevated in peripheral blood mononuclear cells from HIV(+) patients compared with uninfected healthy controls (HCs), and that in vitro inhibition of IDO with the competitive blocker 1-methyl tryptophan (1-mT) results in increased CD4(+) T-cell proliferative response in PBMCs from HIV-infected patients. Expand
Interferon-alpha–induced changes in tryptophan metabolism relationship to depression and paroxetine treatment
TLDR
The results suggest that reduced TRP availability plays a role in IFN-alpha-induced depressive symptoms, and paroxetine, although not altering the KYN or neopterin response to IFn-alpha, attenuates the behavioral consequences ofIFN- alpha-mediated TRP depletion. Expand
HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment.
TLDR
Viral escape in CSF is more common than previously reported, suggesting that low-grade central nervous system infection may continue in treated patients, and the utility of monitoring CSF responses, as new treatment combinations and strategies modify clinical practice is suggested. Expand
Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma
TLDR
It is demonstrated that macrophages stimulated with supernatant from activated T cells release large amounts of neopterin into culture supernatants, indicating that a metabolic pathway so far exclusively known in context with the generation of an essential cofactor of neurotransmitter-synthesis during immune responses is also activated in M phi under stringent control by immune IFN-like lymphokines. Expand
Monitoring tryptophan metabolism in chronic immune activation.
TLDR
Monitoring tryptophan metabolism in chronic immunopathology provides a better understanding of the association between immune activation and IDO and its role in the development of immunodeficiency, anemia and mood disorders. Expand
Potential role of immune system activation-associated production of neopterin derivatives in humans
TLDR
Data support the hypothesis that the release of neopterin enhances the cytotoxic potential of activated macrophages and dendritic cells, and the influence ofNeopterin derivatives on the cellular metabolism may provide an explanation for these clinical observations. Expand
Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load
TLDR
The development of neurologic symptoms in patients on antiretroviral therapy with low or undetectable plasma HIV levels may be an indication of CSF ‘escape’. Expand
Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.
TLDR
IDO-high expression by colorectal tumor cells enables certain cancer subsets to initially avoid immune attack and defeat the invasion of T cells via local tryptophan depletion and the production of proapoptotic tryPTophan catabolites. Expand
The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases.
TLDR
Results of neopterin measurements agree with the important role that the cellular immune system plays in these disorders, including autoimmune disorders and certain malignant diseases. Expand
...
1
2
3
4
5
...