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Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy.
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Peripheral Blood Fibrocytes from Burn Patients: Identification and Quantification of Fibrocytes in Adherent Cells Cultured from Peripheral Blood Mononuclear Cells
TLDR
The results showed that adherent cells cultured from PBMC of burn patients differentiated to fibrocytes more efficiently than did those from normal individuals, and increased TGF-β in serum stimulates the differentiation of the CD14+ cell population in PBMC into collagen-producing cells that may be important in wound healing and scarring.
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Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing.
TLDR
This study reviews current discourse regarding the many roles of TGF-β1 in wound healing by modulating infiltrated immune cells and the extracellular matrix and elucidates the role of keratinocyte/fibroblast cross talk in controlling the later stages of wound healing.
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Uterine insulin-like growth factor-1: regulation of expression and its role in estrogen-induced uterine proliferation.
TLDR
The most dramatic outcome of estrogenization of the immature uterus is the proliferation of various cell types and it is customary to divide the response of the uterus to estrogen into two major temporal phases.
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Cutting Edge: Human Eosinophils Regulate T Cell Subset Selection through Indoleamine 2,3-Dioxygenase1
TLDR
It is shown that human eosinophils constitutively express Indoleamine 2,3-dioxygenase (IDO)-catalyzed conversion of tryptophan to kynurenines (KYN), which regulates T cell function and may maintain Th2 bias through IDO.
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Pathophysiology of chronic nonhealing wounds.
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Hand sanitizers: A review of ingredients, mechanisms of action, modes of delivery, and efficacy against coronaviruses
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Potential application of gaseous nitric oxide as a topical antimicrobial agent.
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Chemical characterization and quantification of proteoglycans in human post-burn hypertrophic and mature scars.
TLDR
The results suggest that aberrant proteoglycan metabolism is a significant factor contributing to the altered physical properties of hypertrophic scars and that maturation of post-burn scars is dependent on a return of the relative proportions and concentrations of proteoglycans to those characteristic of normal dermis.
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14-3-3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage
TLDR
It is shown that 14-3-3η complemented markers such as CRP, RF and ACPA in informing RA radiographic status and/or progression and its expression is higher in patients with radiographic damage and RA progression.
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