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- Publications
- Influence
Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy.
- E. Tredget, B. Nedelec, P. Scott, A. Ghahary
- Medicine
- The Surgical clinics of North America
- 1 June 1997
Keloids, hypertrophic scars, and contractures are a result of aberrations of the normal wound healing process. An understanding of the cellular and molecular events that are implicated in the… Expand
Peripheral Blood Fibrocytes from Burn Patients: Identification and Quantification of Fibrocytes in Adherent Cells Cultured from Peripheral Blood Mononuclear Cells
- L. Yang, P. Scott, J. Giuffre, H. Shankowsky, A. Ghahary, E. Tredget
- Medicine
- Laboratory Investigation
- 1 September 2002
Peripheral blood fibrocytes are a newly identified leukocyte subpopulation that displays fibroblast-like properties. These blood-borne cells can rapidly enter the site of injury at the same time as… Expand
Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing.
- Mohammadreza Pakyari, A. Farrokhi, Mohsen Khosravi Maharlooei, A. Ghahary
- Medicine
- Advances in wound care
- 7 June 2013
SIGNIFICANCE
This review highlights the critical role of transforming growth factor beta (TGF-β)1-3 within different phases of wound healing, in particular, late-stage wound healing. It is also very… Expand
Uterine insulin-like growth factor-1: regulation of expression and its role in estrogen-induced uterine proliferation.
- L. J. Murphy, A. Ghahary
- Biology, Medicine
- Endocrine reviews
- 1 August 1990
THE response of the uterus to estrogen is a complexphenomenon involving numerous biochemical events (1). The most dramatic outcome of estrogenization of the immature uterus is the proliferation of… Expand
Cutting Edge: Human Eosinophils Regulate T Cell Subset Selection through Indoleamine 2,3-Dioxygenase1
- S. Odemuyiwa, A. Ghahary, +5 authors R. Moqbel
- Biology, Medicine
- The Journal of Immunology
- 15 November 2004
Allergy involves eosinophilia and Th2 polarization. Indoleamine 2,3-dioxygenase (IDO)-catalyzed conversion of tryptophan to kynurenines (KYN) regulates T cell function. We show that human eosinophils… Expand
Pathophysiology of chronic nonhealing wounds.
- A. Medina, P. Scott, A. Ghahary, E. Tredget
- Medicine
- The Journal of burn care & rehabilitation
- 1 July 2005
Potential application of gaseous nitric oxide as a topical antimicrobial agent.
- A. Ghaffari, C. C. Miller, B. McMullin, A. Ghahary
- Biology, Medicine
- Nitric oxide : biology and chemistry
- 1 February 2006
The presence of bacterial colonization in non-healing wounds and burn injuries interferes significantly with the normal process of healing. Recent evidence suggests that nitric oxide (NO) plays an… Expand
Hypertrophic scar tissues and fibroblasts produce more transforming growth factor‐β1 mRNA and protein than normal skin and cells
- R. Wang, A. Ghahary, Q. Shen, P. Scott, K. Roy, E. Tredget
- Biology, Medicine
- Wound repair and regeneration : official…
- 1 April 2000
Transforming growth factor‐β1 is a well‐known fibrogenic cytokine produced by many types of cells including dermal fibroblasts. To investigate whether this fibrogenic cytokine is involved in… Expand
Chemical characterization and quantification of proteoglycans in human post-burn hypertrophic and mature scars.
- P. Scott, C. Dodd, E. Tredget, A. Ghahary, F. Rahemtulla
- Chemistry, Medicine
- Clinical science
- 1 May 1996
1. Samples of normal skin from four patients, post-burn hypertrophic scar from five patients and post-burn mature scar from six patients were analysed for hydroxyproline, water and uronic acid and… Expand
Enhanced expression of mRNA for transforming growth factor-beta, type I and type III procollagen in human post-burn hypertrophic scar tissues.
- A. Ghahary, Y. Shen, P. Scott, Y. Gong, E. Tredget
- Biology, Medicine
- The Journal of laboratory and clinical medicine
- 1 October 1993
To explore the possible role of locally synthesized transforming growth factor beta-1 (TGF-beta 1) and procollagen gene expression in postburn hypertrophic scars, we have compared mRNA levels for… Expand