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troxacitabine

Known as: HMD-cytosine, 2R(-)-cis-HMD-cytosine, (-)-ODDC 
A dioxolane derivative and a novel L-configuration deoxycytidine analogue with potent antineoplastic activity. When incorporated into growing chain… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (4)

Anti-HIV AgentsAntineoplastic AgentsCytosineDioxolanes

Narrower (3)

BCH 4556L-OddcTroxatyl
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

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Highly Cited
2004
Highly Cited
2004
Characterization of a Gemcitabine-Resistant Murine Leukemic Cell Line
Resistance to cytotoxic nucleoside analogues is a major problem in cancer treatment. The cellular mechanisms involved in this… 
2004
2004
Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases.
Highly Cited
2002
Highly Cited
2002
Dioxolane Guanosine, the Active Form of the Prodrug Diaminopurine Dioxolane, Is a Potent Inhibitor of Drug‐Resistant HIV‐1 Isolates From Patients for Whom Standard Nucleoside Therapy Fails
Summary: Amdoxovir ([‐]‐&bgr;‐D‐2,6‐diaminopurine dioxolane [DAPD]) is a nucleoside reverse transcriptase inhibitor (NRTI) with… 
2001
2001
Luminance contrast and color recognition in helmet-mounted displays
Although luminance contrast requirements for legibility of text are fairly well established, luminance contrast requirements for… 
2000
2000
The new dioxolane, (-)-2'-deoxy-3'-oxacytidine (BCH-4556, troxacitabine), has activity against pancreatic human tumor xenografts.
There is a great need for new therapeutic agents for patients with advanced pancreatic cancer. The new dioxolane analogue… 
1999
1999
Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys.
(-)-beta-D-Dioxolane guanine (DXG) is a nucleoside analog possessing potent activity against human immunodeficiency virus type 1… 
Highly Cited
1997
Highly Cited
1997
Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models.
Beta-L-Dioxolane-cytidine (BCH-4556) is a novel anticancer nucleoside analogue with a stereochemically unnatural beta-L… 
1996
1996
Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys
(-)-beta-D-2-Aminopurine dioxolane (APD) and (-)-beta-D-2-amino-6-chloropurine dioxolane (ACPD) are recently synthesized… 
1989
1989
A comparison of ventilation strategies for the use of high‐frequency oscillatory ventilation in the treatment of hyaline membrane disease
To assess the efficacy of high frequency oscillatory ventilation (HFOV) in the management of infants with hyaline membrane… 
1984
1984
Effects of prolonged high-frequency oscillatory ventilation in premature primates with experimental hyaline membrane disease.
The effects of 24 h of high-frequency oscillatory ventilation (HFOV) applied to premature primates with hyaline membrane disease… 
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