L-Oddc
National Institutes of Health
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Background Human UMP/CMP kinase was identified based on its enzymatic activity in vitro. The role of this protein is considered…
β-l-Dioxolane-cytidine (l-OddC, Troxacitabine, BCH-4556), a novel l-configuration deoxycytidine analog, is under clinical trials…
Troxacitabine (L-OddC) is an L-configuration deoxycytidine analog currently in phase II trials for the treatment of cancer. The…
Deoxycytidylate deaminase, catalyzing the conversion of dCMP to dUMP, is an important enzyme in the de novo synthesis of…
d-Nucleoside analogs, which are in the natural configuration, as well as the l-nucleoside analogs, are clinically relevant…
In vitro biochemical studies indicate that Ape1 is the major mammalian enzyme responsible for repairing abasic lesions in DNA and…