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Total Tanshinones-Induced Apoptosis and Autophagy Via Reactive Oxygen Species in Lung Cancer 95D Cells.
It is shown that TDT-induced apoptosis and protective autophagy in 95D cells mediated by increasing intracellular ROS production.
Butyrate mediates nucleotide‐binding and oligomerisation domain (NOD) 2‐dependent mucosal immune responses against peptidoglycan
It is inferred that dietary fibres can impact inflammatory bowel diseases based on the results of this study, and a better understanding of the mechanism by which butyrate regulates mucosal immunity for normal intestinal function is provided.
Molecular docking for virtual screening of natural product databases
This mini-review highlights recent examples of the use of molecular docking in virtual screening for the identification of bioactive molecules from natural product databases.
Expression of Deoxynucleotide Carrier Is Not Associated with the Mitochondrial DNA Depletion Caused by Anti-HIV Dideoxynucleoside Analogs and Mitochondrial dNTP Uptake
DNC does not play an important role in the delayed cytotoxicity of anti-HIV dideoxynucleoside analogs and dNTPs uptake into mitochondria, and down-regulation of both DNC and thymidine kinase-2 did not cause mtDNA depletion.
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines
Compound 1 is the first cyclopenta[c]chromen-based KDM5A inhibitor reported, and may serve as a novel motif for developing more selective and efficacious pharmacological molecules targeting KDM6A, and provides a possible anti-cancer mechanism of KDM 5A inhibitors.
Metal complexes as potential modulators of inflammatory and autoimmune responses
In this perspective, we highlight recent examples in the development of transition metal complexes as modulators of inflammatory and autoimmune responses.
Structure Characterization and Immunomodulating Effects of Polysaccharides Isolated from Dendrobium officinale.
  • wei wei, Lei Feng, Q. Han
  • Medicine, Biology
    Journal of agricultural and food chemistry
  • 20 January 2016
Bioassay using mouse macrophage cell line RAW264.7 indicated that DOP and its two subfractions enhance cell proliferation, TNF-α secretion, and phagocytosis in a dose-dependent manner.