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trimetrexate glucuronate

Known as: 2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline mono-D-glucuronate, TMTX, trimetrexate glucuronate [Chemical/Ingredient] 
A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (3)

Drug CombinationsGlucuronatesTrimetrexate

Narrower (2)

NSC 352122Neutrexin
analogs & derivativesdapsone/trimetrexate glucuronatefluorouracil/leucovorin calcium/trimetrexate glucuronate

Papers overview

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Highly Cited
2004
Highly Cited
2004
Comparative genomics of the KdgR regulon in Erwinia chrysanthemi 3937 and other gamma-proteobacteria.
In the plant-pathogenic enterobacterium Erwinia chrysanthemi, almost all known genes involved in pectin catabolism are controlled… 
Review
1998
Review
1998
Biomodulation of Fluorouracil in colorectal cancer.
5-Fluorouracil (5-FU) remains the agent of choice for the treatment of colorectal cancer. Research has focused on the… 
Highly Cited
1997
Highly Cited
1997
Sensitization of hematopoietic stem and progenitor cells to trimetrexate using nucleoside transport inhibitors.
Antifolates such as methotrexate (MTX) and trimetrexate (TMTX) are widely used in the treatment of cancer and nonmalignant… 
Review
1997
Review
1997
Reduced folate carrier gene (RFC1) expression and anti‐folate resistance in transfected and non‐selected cell lines
Methotrexate transport deficiency due to decreased reduced folate carrier (RFC) activity has been observed in several cell lines… 
Highly Cited
1996
Highly Cited
1996
A gene transfer strategy for making bone marrow cells resistant to trimetrexate.
Trimetrexate (TMTX) is an anticancer drug with potential advantages over the more commonly used antifolate, methotrexate (MTX… 
Highly Cited
1995
Highly Cited
1995
Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.
The effects of de novo dTMP inhibition by N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2- thenoyl)-L… 
Highly Cited
1995
Highly Cited
1995
Isolation of the porcine heparin tetrasaccharides with glucuronate 2-O-sulfate. Heparinase cleaves glucuronate 2-O-sulfate-containing disaccharides in highly sulfated blocks in heparin.
Highly Cited
1990
Highly Cited
1990
Trimetrexate in prostatic cancer: preliminary observations on the use of prostate-specific antigen and acid phosphatase as a marker in measurable hormone-refractory disease.
Thirty-one patients with bidimensionally measurable hormone-refractory prostatic cancer received trimetrexate (TMTX). Serial… 
Highly Cited
1966
Highly Cited
1966
Formation of glucose from hexoses, pentoses, polyols and related substances in kidney cortex.
1. Slices of rat kidney cortex, on incubation in a saline medium, formed d-glucose from the following substances: d-fructose, d… 
Highly Cited
1964
Highly Cited
1964
THE CYTOLOGIC DEMONSTRATION OF β-GLUCURONIDASE EMPLOYING NAPHTHOL AS-BI GLUCURONIDE AND HEXAZONIUM PARAROSANILIN; A PRELIMINARY REPORT
The preparation of a new substrate for β-glucuronidase, naphthol AS-BI β-d-glucuronide, has been described. The potassium salt of… 
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