trimetrexate glucuronate

Known as: 2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline mono-D-glucuronate, TMTX, trimetrexate glucuronate [Chemical/Ingredient] 
A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase… (More)
National Institutes of Health

Papers overview

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2010
2010
Using mouse gene knock-out models, we identify aldehyde reductase (EC 1.1.1.2, Akr1a4 (GR)) and aldose reductase (EC 1.1.1.21… (More)
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2004
2004
In the plant-pathogenic enterobacterium Erwinia chrysanthemi, almost all known genes involved in pectin catabolism are controlled… (More)
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2000
2000
In a prospective, randomized, double-blind therapeutic trial, 191 patients with non-alcoholic steatohepatitis were treated for 8… (More)
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1997
1997
Antifolates such as methotrexate (MTX) and trimetrexate (TMTX) are widely used in the treatment of cancer and nonmalignant… (More)
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1996
1996
Trimetrexate (TMTX) is an anticancer drug with potential advantages over the more commonly used antifolate, methotrexate (MTX… (More)
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1995
1995
The effects of de novo dTMP inhibition by N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2- thenoyl)-L… (More)
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1995
1995
Eleven tetrasaccharides were isolated from the repeating disaccharide region of porcine intestinal heparin after strong digestion… (More)
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1992
1992
Although the mechanisms of resistance to methotrexate (MTX) are known in experimental tumors made resistant to this drug, little… (More)
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1990
1990
Thirty-one patients with bidimensionally measurable hormone-refractory prostatic cancer received trimetrexate (TMTX). Serial… (More)
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1989
1989
Trimetrexate glucuronate (TMTX), a nonclassical folate antagonist, has been evaluated clinically on several schedules. We have… (More)
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