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Trimetrexate

Known as: Ipsen Brand of Trimetrexate, 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine, Trimetrexato 
A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the… 
National Institutes of Health

Related topics

Related topics

25 relations

Broader (6)

Antifungal AgentsAntimetabolites, AntineoplasticAntineoplastic AgentsFolic Acid Antagonists
Bone Marrow DiseasesDrug AllergyIn BloodNCIt Antineoplastic Agent Terminology

Narrower (5)

CI-898JB-11NSC 352122NSC-249008

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.
Highly Cited
1997
Highly Cited
1997
Phase II study of trimetrexate, fluorouracil, and leucovorin for advanced colorectal cancer.
PURPOSE A phase II study to evaluate the response rate and toxicities of a trimetrexate, fluorouracil (5FU), and leucovorin… 
1997
1997
Strong inhibition of neuronal nitric oxide synthase by the calmodulin antagonist and anti-estrogen drug tamoxifen.
Highly Cited
1988
Highly Cited
1988
Characterization of trimetrexate transport in human lymphoblastoid cells and development of impaired influx as a mechanism of resistance to lipophilic antifolates.
The purpose of this study was to characterize the transport properties of trimetrexate in WI-L2 human lymphoblastoid cells and… 
1988
1988
Clinical pharmacology and metabolism of trimetrexate.
In non-small cell lung cancer (NSCLC), if the tumor is completely resected in stage I, II, and IIIa disease, the outlook is… 
Highly Cited
1987
Highly Cited
1987
Phase I studies with trimetrexate: clinical pharmacology, analytical methodology, and pharmacokinetics.
Twenty-two patients with advanced solid tumors were treated with a quinazoline folate antagonist, trimetrexate, to determine the… 
1987
1987
Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.
Trimetrexate, a lipid-soluble antifolate, has considerably greater activity in inhibiting the dihydrofolate reductase of… 
Highly Cited
1983
Highly Cited
1983
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Methotrexate (MTX)-resistant sublines of malignant human cells were selected in vitro by stepwise increase in drug concentration… 
Highly Cited
1983
Highly Cited
1983
Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines.
A series of 6-[(arylamino)methyl]-2,4-quinazolinediamines have been prepared by catalytic hydrogenation of the requisite 2,4… 
Highly Cited
1979
Highly Cited
1979
2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline (tmq), a potent non-classical folate antagonist inhibitor--I effect on dihydrofolate reductase and growth of rodent tumors in vitro…
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