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Trimetrexate

Known as: Ipsen Brand of Trimetrexate, 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine, Trimetrexato 
A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the… 
National Institutes of Health

Related topics

Related topics

25 relations

Broader (6)

Antifungal AgentsAntimetabolites, AntineoplasticAntineoplastic AgentsFolic Acid Antagonists
Bone Marrow DiseasesDrug AllergyIn BloodNCIt Antineoplastic Agent Terminology

Narrower (5)

CI-898JB-11NSC 352122NSC-249008

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
PI3K-AKT-mTOR-Signaling and beyond: the Complex Network in Gastroenteropancreatic Neuroendocrine Neoplasms
Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous in their clinical behavior and require therapies specially… 
Highly Cited
2011
Highly Cited
2011
OPTIMIZATION OF MIXING CONDITIONS FOR SILICA-REINFORCED NATURAL RUBBER TIRE TREAD COMPOUNDS
The dump temperature and mixing interval between rubber, silica, and silane coupling agent for silica-filled natural rubber (NR… 
Highly Cited
2007
Highly Cited
2007
Repeated botulinum‐A toxin injections in the treatment of myelodysplastic children and patients with spinal cord injuries with neurogenic bladder dysfunction
Authors from Germany describe the use of botulinum toxin in the treatment of myelodysplastic children and found it to be safe and… 
Highly Cited
2003
Highly Cited
2003
A randomized trial of botulinum toxin A for treatment of drooling
The authors compared the efficacy of three different doses (18.75, 37.5, and 75 MU per parotid gland) of botulinum toxin A (BTX-A… 
Review
2001
Review
2001
Acute graft-vs-host disease: pathobiology and management.
Review
1996
Review
1996
Intrinsic and acquired resistance to methotrexate in acute leukemia.
Methotrexate, a folic acid antagonist, is used extensively not only for the treatment of cancer but also for the treatment of… 
Highly Cited
1987
Highly Cited
1987
Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome.
Preclinical studies have demonstrated that trimetrexate is a potent inhibitor of dihydrofolate reductase from Pneumocystis… 
Highly Cited
1987
Highly Cited
1987
Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.
Highly Cited
1984
Highly Cited
1984
A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates.
Highly Cited
1982
Highly Cited
1982
Caffeine disposition after oral doses
Caffeine (TMX) disposition was studied in men after 1, 5, and 10 mg/kg in water, as mocha coffee (1.54 mg/kg) and as a soft drink… 
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