Trimetrexate

Known as: Ipsen Brand of Trimetrexate, 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine, Trimetrexato 
A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the… (More)
National Institutes of Health

Papers overview

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2007
2007
OBJECTIVE This randomised, double blind, placebo controlled, two parallel group study was conducted to assess the beneficial… (More)
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Highly Cited
2003
Highly Cited
2003
The authors compared the efficacy of three different doses (18.75, 37.5, and 75 MU per parotid gland) of botulinum toxin A (BTX-A… (More)
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Highly Cited
1995
Highly Cited
1995
This study examines (a) the relation of initial treatment motivations to alcoholics' involvement in outpatient treatment and… (More)
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1987
1987
Preclinical studies have demonstrated that trimetrexate is a potent inhibitor of dihydrofolate reductase from Pneumocystis… (More)
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Review
1987
Review
1987
Trimetrexate is a promising new lipophilic antifolate with antitumor and antimicrobial activity, which is currently undergoing… (More)
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1987
1987
Twenty-two patients with advanced solid tumors were treated with a quinazoline folate antagonist, trimetrexate, to determine the… (More)
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1986
1986
The pharmacokinetics of trimetrexate was studied in Rhesus monkeys following i.v. bolus, continuous i.v. infusion, oral, and… (More)
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1985
1985
Trimetrexate, a 2,4-diaminoquinazoline derivative, is a new antifol recently introduced into clinical trials. It differs from… (More)
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1984
1984
Trimetrexate is a novel lipophilic folate antagonist that causes growth inhibition, inhibition of nucleic acid biosynthesis, and… (More)
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Highly Cited
1982
Highly Cited
1982
Caffeine (TMX) disposition was studied in mean after 1, 5, and 10 mg/kg in water, as mocha coffee (1.54 mg/kg) and as a soft… (More)
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