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treosulfan

Known as: Tresulfon, L-threitol-1,4-bismethanesulfonate, Treosulphan 
The prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppressive, and antineoplastic activities. Under physiological… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Antineoplastic Agents, AlkylatingBusulfan
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Narrower (1)

Ovastat

Papers overview

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2016
2016
A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency
Highly Cited
2016
Highly Cited
2016
European Society for Blood and Marrow Transplantation Analysis of Treosulfan Conditioning Before Hematopoietic Stem Cell Transplantation in Children and Adolescents With Hematological Malignancies
Standard myeloablative conditioning regimens for children with hematological malignancies undergoing allogeneic HSCT are based… 
2006
2006
Cytotoxicity of treosulfan and busulfan on pediatric tumor cell lines
High-dose chemotherapy of solid tumors aims at eliminating residual or metastatic tumor cells, which remained after conventional… 
2005
2005
Phase I trial combining gemcitabine and treosulfan in advanced cutaneous and uveal melanoma patients
Gemcitabine and treosulfan are DNA-damaging agents. Preclinical studies suggest that synergism exists when melanoma cells are… 
1999
1999
Treosulfan is an effective alkylating cytostatic for malignant melanoma in vitro and in vivo.
The therapy of metastatic malignant melanoma is limited by poor responses and short overall survival. Thus it remains an… 
Highly Cited
1998
Highly Cited
1998
Treosulfan as an effective second-line therapy in ovarian cancer.
Despite radical surgery and aggressive platinum-containing primary chemotherapy, the outcome of patients with advanced ovarian… 
1996
1996
A Phase I Dose Escalation Trial of Intravenous Treosulfan in Refractory Cancer
Background: Treosulfan (Ovastat®), a bifunctional alkylating cytostatic, indicated for the treatment of advanced ovarian… 
1990
1990
Intravenous treosulfan versus intravenous treosulfan plus cisplatinum in advanced ovarian carcinoma
Summary. In a prospective, multicentre, randomized trial, the efficacy and tolerance of treosulfan alone was compared with that… 
1989
1989
Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4‐aminobiphenyl, treosulphan, and melphalan
Three human carcinogens, 4‐aminobiphenyl, treosulphan, and melphalan, were tested for the induction of micronuclei or chromosomal… 
1984
1984
The chemosensitivity of a new experimental model--the M5076 reticulum cell sarcoma.
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