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treosulfan

Known as: Tresulfon, L-threitol-1,4-bismethanesulfonate, Treosulphan 
The prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppressive, and antineoplastic activities. Under physiological… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Antineoplastic Agents, AlkylatingBusulfan
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Narrower (1)

Ovastat

Papers overview

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Highly Cited
2017
Highly Cited
2017
T‐cell receptor &agr;&bgr;+ and CD19+ cell–depleted haploidentical and mismatched hematopoietic stem cell transplantation in primary immune deficiency
Highly Cited
2016
Highly Cited
2016
Treosulfan-based conditioning for allogeneic HSCT in children with chronic granulomatous disease: a multicenter experience.
Chronic granulomatous disease (CGD) can be cured by allogeneic hemopoietic stem cell transplantation (HSCT). Complications… 
Highly Cited
2016
Highly Cited
2016
TCR-alpha/beta and CD19 depletion and treosulfan-based conditioning regimen in unrelated and haploidentical transplantation in children with acute myeloid leukemia
We evaluated the depletion of TCR-alpha/beta cells from the graft of children with high-risk AML, who received transplantation… 
Review
2013
Review
2013
Pharmacology of dimethanesulfonate alkylating agents: busulfan and treosulfan
Introduction: Among the dimethanesulfonates, busulfan, in combination with other alkylating agents or nucleoside analogues, is… 
Highly Cited
2012
Highly Cited
2012
Allogeneic hematopoietic stem cell transplantation in thalassemia major: results of a reduced-toxicity conditioning regimen based on the use of treosulfan.
Sixty thalassemia patients (median age, 7 years; range, 1-37) underwent allogeneic hematopoietic stem cell transplantation (HSCT… 
Review
2012
Review
2012
Reduced-intensity conditioning for allogeneic stem cell transplant in primary immune deficiencies
Conventional myeloablative conditioning regimens prior to hematopoietic cell transplantation (HCT) are associated with… 
Highly Cited
2010
Highly Cited
2010
Allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies after dose-escalated treosulfan/fludarabine conditioning.
PURPOSE Treosulfan was introduced recently as a conditioning agent for allogeneic blood stem-cell transplantation. The favorable… 
Highly Cited
2005
Highly Cited
2005
Dose-escalated treosulphan in combination with cyclophosphamide as a new preparative regimen for allogeneic haematopoietic stem cell transplantation in patients with an increased risk for regimen…
Summary:Treosulphan has recently demonstrated antileukaemic activity and potent haematopoietic stem cell toxicity. Dose-escalated… 
Highly Cited
2004
Highly Cited
2004
Treosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation.
New conditioning regimens are being explored to reduce toxicity and enable allogeneic bone marrow transplantation in patients not… 
Review
1988
Review
1988
The genetic toxicity of human carcinogens and its implications.
  • M. Shelby
  • Mutation research
  • 1988
  • Corpus ID: 20700728
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