treosulfan

Known as: Tresulfon, L-threitol-1,4-bismethanesulfonate, Treosulphan 
The prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppressive, and antineoplastic activities. Under physiological… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Sixty thalassemia patients (median age, 7 years; range, 1-37) underwent allogeneic hematopoietic stem cell transplantation (HSCT… (More)
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2006
2006
OBJECTIVE Treosulfan is a prodrug with a specific clinical activity in ovarian carcinoma and other solid tumors. Due to its… (More)
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2006
2006
8018 Background: In-vitro studies have suggested synergy of gemcitabine and treosulfan against uveal melanoma cells, and the… (More)
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Highly Cited
2004
Highly Cited
2004
New conditioning regimens are being explored to reduce toxicity and enable allogeneic bone marrow transplantation in patients not… (More)
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2000
2000
A Phase I dose escalation and pharmacokinetic study of the alkylating cytotoxic agent treosulfan was conducted to evaluate the… (More)
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1999
1999
SummaryThe anti-tumour drug treosulfan (L-threitol 1,4-bismethanesulphonate, Ovastat) is a prodrug for epoxy compounds by… (More)
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1998
1998
Despite radical surgery and aggressive platinum-containing primary chemotherapy, the outcome of patients with advanced ovarian… (More)
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1990
1990
In a prospective, multicentre, randomized trial, the efficacy and tolerance of treosulfan alone was compared with that of… (More)
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Review
1988
Review
1988
23 chemicals and chemical combinations have been designated by the International Agency for Research on Cancer (IARC) as causally… (More)
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Highly Cited
1985
Highly Cited
1985
Of 602 patients treated for non-Hodgkin's lymphomas, 9 developed overt acute nonlymphocytic leukemia or preleukemia with… (More)
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