European Society for Blood and Marrow Transplantation Analysis of Treosulfan Conditioning Before Hematopoietic Stem Cell Transplantation in Children and Adolescents With Hematological Malignancies.

@article{Boztug2016EuropeanSF,
  title={European Society for Blood and Marrow Transplantation Analysis of Treosulfan Conditioning Before Hematopoietic Stem Cell Transplantation in Children and Adolescents With Hematological Malignancies.},
  author={Heidrun Boztug and K W Sykora and Mary Anne Slatter and Marco Zecca and Paul A Veys and Arjan C Lankester and Andrew J. Cant and Roderick Skinner and Jacek Wachowiak and Evgenia Glogova and Ulrike Poetschger and Christina Peters},
  journal={Pediatric blood & cancer},
  year={2016},
  volume={63 1},
  pages={
          139-48
        }
}
BACKGROUND Standard myeloablative conditioning regimens for children with hematological malignancies undergoing allogeneic HSCT are based mainly on total body irradiation or busulfan. Their serious short- and long-term side effects warranted the exploration of less toxic alternatives. Treosulfan is increasingly used for adults and children before HSCT due to its potent immunosuppressive and cytotoxic effects combined with low organ toxicity. PROCEDURE To further investigate the role of… CONTINUE READING
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Disposition of treosulfan and its active monoepoxide in a bone marrow, liver, lungs, brain, and muscle: Studies in a rat model with clinical relevance

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2017
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CITES BACKGROUND & METHODS
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