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tomopenem

A 1-beta-methylcarbapenem antibiotic with broad-spectrum activity against gram-positive and gram-negative bacteria. Tomopenem has a longer half-life… 
National Institutes of Health

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Related topics

3 relations

Narrower (2)

CS 023R 115685

Broader (1)

Carbapenems

Papers overview

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2014
2014
An enzoinformatics study for prediction of efficacies of three novel penem antibiotics against New Delhi metallo-β-lactamase-1 bacterial enzyme
New Delhi metallo-beta-lactamase (NDM-1) is a beta-lactamase (class B carbapenemase) containing Zn2+ and other divalent cations… 
2010
2010
In vitro postantibiotic effects of tomopenem (CS-023) against Staphylococcus aureus and Pseudomonas aeruginosa.
The postantibiotic effect (PAE) of tomopenem was determined after a 2 h exposure of two strains of meticillin-susceptible and… 
2009
2009
Lack of age and gender effects on single-dose pharmacokinetics of tomopenem (RO4908463/CS-023), a novel carbapenem.
AIMS To investigate the effect of age and gender on the tolerability, safety and pharmacokinetics (PK) of tomopenem (RO4908463/CS… 
2008
2008
Potent In Vitro Activity of Tomopenem (CS-023) against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa
ABSTRACT Tomopenem (formerly CS-023) is a novel 1β-methylcarbapenem with broad-spectrum coverage of gram-positive and gram… 
2008
2008
In Vitro Activity of Tomopenem (CS-023/RO4908463) against Anaerobic Bacteria
ABSTRACT The antianaerobic activity of tomopenem, a new longer-half-life parenteral carbapenem, was compared with other… 
2008
2008
Effect of Impaired Renal Function on the Pharmacokinetics of Tomopenem (RO4908463/CS-023), a Novel Carbapenem
ABSTRACT The objective of this study was to assess the impact of impaired renal function on the pharmacokinetics of tomopenem… 
2008
2008
In Vivo Pharmacodynamic Activity of Tomopenem (formerly CS-023) Against Pseudomonas aeruginosa and MRSA in Murine Thigh Infection Model
2008
2008
In Vivo Efficacy of Tomopenem (formerly CS-023) Human-Simulated Exposure Against Pseudomonas aeruginosa and MRSA
2007
2007
Gateways to clinical trials.
1E10, 101M; AAV-ASPA, agomelatine, aliskiren fumarate, alvimopan hydrate, ambrisentan, apaziquone, axitinib; Becatecarin… 
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