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Substrate Specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM Efflux Pumps in Pseudomonas aeruginosa
TLDR
To find the exact substrate specificities of three species of tripartite efflux systems of Pseudomonas aeruginosa, MexAB-OprM, MexCD- oprJ, and MexXY-OPRM, a series of isogenic mutants were constructed, each constitutively overproduced one of the three efflux system and lacked the other two. Expand
Regulatory network of acid resistance genes in Escherichia coli
TLDR
Results suggest that EvgA binds to the inverted repeats and upregulates the downstream genes, suggesting that several genes orchestrate YdeO‐induced acid resistance. Expand
Contribution of the MexX-MexY-OprM Efflux System to Intrinsic Resistance in Pseudomonas aeruginosa
TLDR
The results suggest that MexXY induced by these agents is functionally associated with spontaneously expressed OprM and contributes to the intrinsic resistance to these agents. Expand
Escherichia coli Gene Expression Responsive to Levels of the Response Regulator EvgA
TLDR
YhiUV induced by EvgA overexpression is functionally associated with TolC and contributes to multidrug resistance, suggesting that YhiE plays a critical role in stationary-phase acid resistance. Expand
Characterization of EvgAS-YdeO-GadE Branched Regulatory Circuit Governing Glutamate-Dependent Acid Resistance in Escherichia coli
TLDR
A microarray study using overexpressed regulators uncovered evgAS and ydeO as potential regulators of gadE, now known to encode the essential activator of the gadA and gadBC genes, and revealed that GadE was autoinduced. Expand
Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa
TLDR
Three types of multiple-drug-resistant mutants which were phenotypically similar to previously described nalB, nfxB, and nfxC mutants were isolated from Pseudomonas aeruginosa PAO1 and two clinical isolates, suggesting that at least three different outer membrane proteins, OprM, OPRJ, and OprN, are associated with multiple drug resistance in P. aerug inosa. Expand
Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa
  • N. Masuda, S. Ohya
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 1 September 1992
TLDR
The data suggest that overproduction of OprM is associated with cross-resistance to meropenem, cephems, and quinolones in P. aeruginosa. Expand
Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa
TLDR
Results suggest that there are at least two nfxB mutations that show different phenotypes and that production of OprJ is associated with changes in susceptibilities of NfxB mutants. Expand
Interplay between Chromosomal β-Lactamase and the MexAB-OprM Efflux System in Intrinsic Resistance to β-Lactams inPseudomonas aeruginosa
TLDR
The intrinsic resistance of P. aeruginosa to most of the β-lactams is due to the interplay of both factors, and the role of chromosomal β- lactamase and the MexAB-OprM efflux system is investigated. Expand
Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa.
TLDR
The intrinsic resistance of P. aeruginosa to most of the beta-lactams is due to the interplay of both factors, and the role of chromosomal beta- lactamase and the MexAB-OprM efflux system is investigated. Expand
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