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tirilazad

Known as: Pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-16-methyl-, (16alpha)-, monomethanesulfonate, tirilazad [Chemical/Ingredient] 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

AntioxidantsNeuroprotective AgentsPregnatrienes

Narrower (3)

FreedoxU 74006Ftirilazad mesylate hydrate

Papers overview

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2004
2004
Neuroprotection in ischemic stroke—combination drug therapy and mild hypothermia in a rat model of permanent focal cerebral ischemia
Review
2001
Review
2001
Antioxidant therapy in neurologic disease.
Review
2001
Review
2001
Special Article Pharmacological Treatment Of Acute Spinal Cord Injury: How Do We Build On Past Success?
Abstract Most acute spinal cord injuries (SCI) do not involve complete transection of the spinal cord; typically, a rim of white… 
1999
1999
Venous Irritation, Pharmacokinetics, and Tissue Distribution of Tirilazad in Rats Following Intravenous Administration of a Novel Supersaturated Submicron Lipid Emulsion
AbstractPurpose. To compare the venous irritation, pharmacokinetics, and tissue distribution of tirilazad in rats after… 
1999
1999
Population Pharmacokinetics of Tirilazad: Effects of Weight, Gender, Concomitant Phenytoin, and Subarachnoid Hemorrhage
AbstractPurpose. Data collected during Phase I and II in the development of tirilazad were pooled and analyzed using nonlinear… 
1997
1997
Effects of nalmefene, CG3703, tirilazad, or dopamine on cerebral blood flow, oxygen delivery, and electroencephalographic activity after traumatic brain injury and hemorrhage.
Hemorrhage after traumatic brain injury (TBI) in cats produces significant decreases in cerebral oxygen delivery (DcereO2) and… 
1996
1996
Amelioration of impaired cerebral metabolism after severe acidotic ischemia by tirilazad posttreatment in dogs.
BACKGROUND AND PURPOSE Acidosis may contribute to ischemic injury by mobilizing iron because the iron chelator deferoxamine… 
1996
1996
Chapter 34. To Market, To Market - 1995
1996
1996
Changes in local microvascular permeability and in the effect of intervention with 21-aminosteroid (Tirilazad) in a new experimental model of focal cortical injury in the rat.
In a new, reproducible model of rodent focal cortical injury, we have shown that in the absence of early traumatic disruption of… 
1994
1994
Therapeutic efficacy of tirilazad in experimental multiple cerebral emboli: A randomized, controlled trial
ObjectiveA significant proportion of patients who undergo cardiac surgery or carotid endar-terectomy appear to develop subtle… 
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