tirilazad mesylate hydrate

Known as: 21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)-triene-3,20-dione monomethane sulfonate, tirilazad mesylate 
 
National Institutes of Health

Papers overview

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Review
2008
Review
2008
In the United States stroke is the third leading cause of death and the leading cause of disability. Brain injury following… (More)
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Highly Cited
2000
Highly Cited
2000
Five parkinsonian patients were transplanted bilaterally into the putamen and caudate nucleus with human embryonic mesencephalic… (More)
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Highly Cited
1999
Highly Cited
1999
OBJECT Findings from previous multicenter clinical trials have suggested that tirilazad mesylate, a synthetic nonhormonal 21… (More)
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1999
1999
BACKGROUND AND PURPOSE Hypothermia has been suggested to be the most potent therapeutic approach to reduce experimental ischemic… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECT A randomized double-blind clinical trial was conducted to compare neurological and functional recovery and morbidity and… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECT The authors prospectively studied the efficacy of tirilazad mesylate, a novel aminosteroid, in humans with head injuries… (More)
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Highly Cited
1997
Highly Cited
1997
OBJECTIVE To compare the efficacy of methylprednisolone administered for 24 hours with methyprednisolone administered for 48… (More)
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Highly Cited
1993
Highly Cited
1993
Preincubation of red blood cell membranes in the presence of ferrous sulfate and EDTA resulted in both a concentration- and time… (More)
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Review
1992
Review
1992
Oxygen radical-mediated lipid peroxidation (LP) has been suggested increasingly to be an important factor in posttraumatic… (More)
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1992
1992
BACKGROUND AND PURPOSE We examined the cytoprotective effect of the lipid peroxidation inhibitor tirilazad mesylate (U74006F) in… (More)
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