thymocyte

Known as: Thymic lymphocyte, Thymocytes 
A cell that develops in the thymus, seemingly from a stem cell of bone marrow and of fetal liver, and is the precursor of the thymus-derived… (More)
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
Mammalian Kruppel-like transcription factors are implicated in regulating terminal differentiation of several tissue types… (More)
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Highly Cited
2005
Highly Cited
2005
Efficient generation of regulatory T cells (Treg cells) in the thymus requires CD28 costimulation, but it is not known why. Here… (More)
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Highly Cited
2002
Highly Cited
2002
During lymphocyte development, the assembly of genes coding for antigen receptors occurs by the combinatorial linking of gene… (More)
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Highly Cited
2000
Highly Cited
2000
Phosphoinositide 3-kinases (PI3Ks) regulate fundamental cellular responses such as proliferation, apoptosis, cell motility, and… (More)
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Highly Cited
1994
Highly Cited
1994
We have used organ culture of fetal thymic lobes from T cell receptor (TCR) transgenic beta 2M(-/-) mice to study the role of… (More)
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Highly Cited
1993
Highly Cited
1993
DEATH by apoptosis is characteristic of cells undergoing deletion during embryonic development, T- and B-cell maturation and… (More)
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Highly Cited
1993
Highly Cited
1993
THE p53 tumour suppressor gene is the most widely mutated gene in human tumorigenesis1,2. p53 encodes a transcriptional… (More)
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Highly Cited
1992
Highly Cited
1992
THE protein Lck (p56lck) has a relative molecular mass of 56,000 and belongs to the Src family of tyrosine kinases1–3. It is… (More)
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Highly Cited
1990
Highly Cited
1990
In order to examine the mechanisms by which clonal deletion of autoreactive T cells occurs, a peptide antigen was used to induce… (More)
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Highly Cited
1988
Highly Cited
1988
The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for… (More)
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