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FASLG protein, human

Known as: FASL protein, human, Fas ligand (TNF superfamily, member 6), human, FAS-Ligand 
Tumor necrosis factor ligand superfamily member 6 (281 aa, ~31 kDa) is encoded by the human FASLG gene. This protein plays a role in the positive… 
National Institutes of Health

Related topics

Related topics

24 relations
AKT Signaling PathwayApoptosisApoptosis PromoterApoptosis Regulatory Proteins

Broader (1)

Tumor Necrosis Factor Ligand Superfamily Member 6

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Surface Tethered Epidermal Growth Factor Protects Proliferating and Differentiating Multipotential Stromal Cells from FasL‐Induced Apoptosis
Multipotential stromal cells or mesenchymal stem cells (MSCs) have been proposed as aids in regenerating bone and adipose tissues… 
Highly Cited
2006
Highly Cited
2006
Porphyromonas gingivalis enhances FasL expression via up-regulation of NFkappaB-mediated gene transcription and induces apoptotic cell death in human gingival epithelial cells.
The interaction between epithelial cells and micro-organisms is often a crucial initiating event in infectious diseases… 
Highly Cited
2006
Highly Cited
2006
The Cytoplasmic Domain of Fas Ligand Costimulates TCR Signals1
Productive T cell activation generally requires costimulation in addition to a signal delivered through the TCR. Although FasL is… 
Review
2005
Review
2005
Impaired apoptosis and immune senescence – cause or effect?
Summary:  Aged animals and humans exhibit a decreased T‐cell activation response although they also exhibit increased… 
Highly Cited
2004
Highly Cited
2004
Sustained Activation of p38 Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase Pathways by Hepatitis B Virus X Protein Mediates Apoptosis via Induction of Fas/FasL and Tumor Necrosis Factor…
ABSTRACT Activation of the cellular stress pathways (c-Jun N-terminal kinase [JNK] and p38 mitogen-activated protein [MAP] kinase… 
Highly Cited
2003
Highly Cited
2003
Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells
Activation of Akt signalling pathway is frequently found in glioma cells and may contribute to their resistance to undergo… 
Highly Cited
2003
Highly Cited
2003
CD95/Fas signaling in human melanoma cells: conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human…
The significance of CD95/Fas ligand expression by melanoma cells has remained a controversial matter in recent years. On the… 
Highly Cited
2001
Highly Cited
2001
A complex adenovirus vector that delivers FASL-GFP with combined prostate-specific and tetracycline-regulated expression.
Cell-type-restricted transgene expression delivered by adenovirus vectors is highly desirable for gene therapy of cancer, as it… 
Highly Cited
1999
Highly Cited
1999
Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis
Recent studies have suggested that MAP kinase phosphatase 1 (MKP-1) is overexpressed in prostate cancer. To evaluate the role of… 
Highly Cited
1999
Highly Cited
1999
Doxycycline induces Fas/Fas ligand-mediated apoptosis in Jurkat T lymphocytes.
Tetracyclines have been used in the treatment of chronic inflammatory diseases associated with local infiltration of inflammatory… 
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