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thiocarlide

Known as: 4,4'-diisoamyloxythiocarbanilide, isoxyl, tiocarlid 
 
National Institutes of Health

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2015
2015
ABSTRACTDehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium… Expand
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2013
2013
The mechanism by which the antitubercular drug isoxyl (ISO) inhibits mycolic acid biosynthesis has not yet been reported. We… Expand
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2012
2012
Isoxyl (ISO) and thiacetazone (TAC), two prodrugs once used in the clinical treatment of tuberculosis, have long been thought to… Expand
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2011
2011
The thioamide and thiourea class of antituberculosis agents encompasses prodrugs that are oxidatively converted to their active… Expand
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Highly Cited
2007
Highly Cited
2007
Many of the current antimycobacterial agents require some form of cellular activation unmasking reactive groups, which in turn… Expand
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2006
2006
Symmetrical and unsymmetrical analogues of the antimycobacterial agent isoxyl have been synthesized and tested against… Expand
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Highly Cited
2004
Highly Cited
2004
The response of Mycobacterium tuberculosis to six anti-microbial agents was determined by microarray analysis in an attempt to… Expand
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Highly Cited
2003
Highly Cited
2003
The thiourea isoxyl (thiocarlide; 4,4'-diisoamyloxydiphenylthiourea) is known to be an effective anti-tuberculosis drug, active… Expand
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Highly Cited
2000
Highly Cited
2000
Ethionamide (ETA) is an important component of second-line therapy for the treatment of multidrug-resistant tuberculosis… Expand
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Highly Cited
1999
Highly Cited
1999
Isoxyl (ISO), a thiourea (thiocarlide; 4, 4'-diisoamyloxythiocarbanilide), demonstrated potent activity against Mycobacterium… Expand
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