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DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells
- L. Tailleux, O. Schwartz, O. Neyrolles
- Biology, MedicineThe Journal of experimental medicine
- 6 January 2003
It is shown that M. tuberculosis enters human monocyte-derived DCs after binding to the recently identified lectin DC-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN), which is likely to influence bacterial persistence and host immunity.
INHIBITION OF MYCOLIC ACID TRANSPORT ACROSS THE MYCOBACTERIUM TUBERCULOSIS PLASMA MEMBRANE
Experiments revealed that the prototype inhibitor targets the inner membrane transporter, MmpL3, and support the involvement of this transporter in the translocation of trehalose monomycolate across the plasma membrane.
Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis.
- V. Pelicic, M. Jackson, J. Reyrat, W. Jacobs, B. Gicquel, C. Guilhot
- BiologyProceedings of the National Academy of Sciences…
- 30 September 1997
A system enabling the positive selection of insertional mutants having lost the delivery vector was developed, which allowed the construction of M. tuberculosis transposition mutant libraries and is efficient for gene exchange mutagenesis.
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
The optimized IPA compound Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range and was efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight, which highlights the potency of this compound.
The Ser/Thr Protein Kinase PknB Is Essential for Sustaining Mycobacterial Growth
It is shown that the pknB gene can be disrupted by allelic replacement in M. tuberculosis and the saprophyte Mycobacterium smegmatis only in the presence of a second functional copy of the gene.
The Cell Surface Receptor DC-SIGN Discriminates betweenMycobacterium Species through Selective Recognition of the Mannose Caps on Lipoarabinomannan*
The results provide molecular insight into the mechanisms of mycobacteria-DC-SIGN interaction, and suggest that DC-SIGN may act as a pattern recognition receptor and discriminate between Mycobacterium species through selective recognition of the mannose caps on LAM molecules.
Definition of the First Mannosylation Step in Phosphatidylinositol Mannoside Synthesis
It is demonstrated here that the pimA mutant is unable to grow at the higher temperature at which the rescue plasmid is lost, providing the first direct evidence of the essentiality of phosphatidylinositol mannosides for the growth of mycobacteria.
Unique Mechanism of Action of the Thiourea Drug Isoxyl on Mycobacterium tuberculosis*
- Benjawan Phetsuksiri, M. Jackson, P. Brennan
- Biology, ChemistryJournal of Biological Chemistry
- 26 December 2003
It is demonstrated that isoxyl results in a dose-dependent decrease in the synthesis of oleic and tuberculostearic acid in M. tuberculosis with complete inhibition at 3 μg/ml, validate membrane-bound Δ9-desaturase, DesA3, as a new therapeutic target, and the thioureas as anti-tuberculosis drugs worthy of further development.
Molecular Recognition and Interfacial Catalysis by the Essential Phosphatidylinositol Mannosyltransferase PimA from Mycobacteria*
A novel mode of phosphatidylinositol recognition is revealed and this association leads to enzyme activation, providing a template for the development of potential antimycobacterial compounds.