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New chemotherapeutics active against multidrug-resistant Mycobacterium tuberculosis (M. tb) are urgently needed. We report on the identification of an adamantyl urea compound displaying potentExpand
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Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis.
A better understanding of Mycobacterium tuberculosis virulence mechanisms is highly dependent on the design of efficient mutagenesis systems. A system enabling the positive selection of insertionalExpand
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The Cell Surface Receptor DC-SIGN Discriminates betweenMycobacterium Species through Selective Recognition of the Mannose Caps on Lipoarabinomannan*
Interactions between dendritic cells (DCs) and Mycobacterium tuberculosis, the etiological agent of tuberculosis, most likely play a key role in anti-mycobacterial immunity. We have recently shownExpand
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The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth.
The receptor-like protein kinase PknB from Mycobacterium tuberculosis is encoded by the distal gene in a highly conserved operon, present in all actinobacteria, that may control cell shape and cellExpand
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Definition of the First Mannosylation Step in Phosphatidylinositol Mannoside Synthesis
We examined the function of the pimA(Rv2610c) gene, located in the vicinity of the phosphatidylinositol synthase gene in the genomes of Mycobacterium tuberculosisand Mycobacterium smegmatis, whichExpand
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The structure of PknB in complex with mitoxantrone, an ATP‐competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria
Mycobacterium tuberculosis PknB is an essential receptor‐like protein kinase involved in cell growth control. Here, we demonstrate that mitoxantrone, an anthraquinone derivative used in cancerExpand
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Molecular Recognition and Interfacial Catalysis by the Essential Phosphatidylinositol Mannosyltransferase PimA from Mycobacteria*
Mycobacterial phosphatidylinositol mannosides (PIMs) and metabolically derived cell wall lipoglycans play important roles in host-pathogen interactions, but their biosynthetic pathways are poorlyExpand
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Lipoarabinomannan of Mycobacterium: Mannose capping by a multifunctional terminal mannosyltransferase
Biosynthesis of phosphatidylinositol (PI)-containing lipoarabinomannan (LAM) and lipomannan (LM) of Mycobacterium spp. follows a conserved pathway involving multiple membrane-associated,Expand
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Phosphatidylinositol Is an Essential Phospholipid of Mycobacteria*
Phosphatidylinositol (PI) and metabolically derived products such as the phosphatidylinositol mannosides and linear and mature branched lipomannan and lipoarabinomannan are prominentExpand
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Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis
ABSTRACT MmpL3, a resistance-nodulation-division (RND) superfamily transporter, has been implicated in the formation of the outer membrane of Mycobacterium tuberculosis; specifically, MmpL3 isExpand
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