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The envelope of mycobacteria.
Differences in mycolic acid structure may affect the fluidity and permeability of the bilayer, and may explain the different sensitivity levels of various mycobacterial species to lipophilic inhibitors.
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
It is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs), and that Activation of TLRs by microbes may initiate innate defense mechanisms against infectious pathogens.
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
Recent advances in understanding of the innate-like mechanisms underlying iNKT cell activation are discussed and how lipid antigens, the inflammatory milieu and interactions with other immune cell subsets regulate the functions of iN KT cells in health and disease are described.
Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis.
- P. Brennan
- Biology, MedicineTuberculosis
- 1 February 2003
Definition of the genome of M. tuberculosis has greatly aided efforts to define the biosynthetic pathways for all of these exotic molecules: the mycolic acids, the mycocerosates, phthiocerol, LAM, and the polyprenyl phosphates.
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis.
- J. Belisle, V. Vissa, T. Sievert, K. Takayama, P. Brennan, G. Besra
- Biology, MedicineScience
- 30 May 1997
A carboxylesterase domain was found within the amino acid sequences of Ag85A, B, and C, and each protein acted as a mycolyltransferase involved in the final stages of mycobacterial cell wall assembly, as shown by direct enzyme assay and site-directed mutagenesis.
Deciphering the transcriptional network of the dendritic cell lineage - eScholarship
A transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens is identified and predicted regulators of DC functional diversity in tissues are predicted.
Comparative genomic and phylogeographic analysis of Mycobacterium leprae
Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world and showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy.
Activation of the pro-drug ethionamide is regulated in mycobacteria.
- A. Baulard, J. Betts, +5 authors G. Besra
- Chemistry, MedicineThe Journal of biological chemistry
- 8 September 2000
New avenues of research relating to ETH activation in mycobacteria are opened up, possibly leading to an improved efficacy of ETH and to the generation of new anti-mycobacterial agents.
A novel pathogenic taxon of the Mycobacterium tuberculosis complex, Canetti: characterization of an exceptional isolate from Africa.
- D. van Soolingen, T. Hoogenboezem, +9 authors J. V. van Embden
- Biology, MedicineInternational journal of systematic bacteriology
- 1 October 1997
This study supports the idea that the established members within the M. tuberculosis complex and the newly described Canetti grouping should be regarded as a single species, which likely will be designated "M. tuberculosis".
CD1-restricted T cell recognition of microbial lipoglycan antigens.
It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes, which resulted in T cells activated by LAM producing interferon gamma and were cytolytic.