G. Besra

Publications653
h-index102
Citations32,421
Highly Influential Citations1,384
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Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis
TLDR
This work proposes a detailed pathway to the biosynthesis of all mycolic acids in M. tuberculosis and lists candidate genes in the genome that encode the proposed mycolyltransferases I and II, phosphatase, and ABC transporter. Expand
CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor
TLDR
The structure provides a basis for the interaction between the highly conserved NKT TCR α-chain and the CD1d–antigen complex that is typified in innate immunity, and indicates how variability of the N KT TCR β-chain can impact on recognition of other CD1D–antigens complexes. Expand
Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum
TLDR
Transcript analyses refute the hypothesis that these cells predominate in sputum and reinforce the results of the lipid body analyses by revealing transcriptional signatures that can be clearly attributed to slowly replicating or nonreplicating mycobacteria. Expand
Activation of the pro-drug ethionamide is regulated in mycobacteria.
TLDR
New avenues of research relating to ETH activation in mycobacteria are opened up, possibly leading to an improved efficacy of ETH and to the generation of new anti-mycobacterial agents. Expand
A novel pathogenic taxon of the Mycobacterium tuberculosis complex, Canetti: characterization of an exceptional isolate from Africa.
TLDR
This study supports the idea that the established members within the M. tuberculosis complex and the newly described Canetti grouping should be regarded as a single species, which likely will be designated "M. tuberculosis". Expand
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue
TLDR
The adipose iNKT cells were a tissue-resident population that induced an anti-inflammatory phenotype in macrophages and, through the production of IL-2, controlled the number, proliferation and suppressor function of regulatory T cells (Treg cells) in adipose tissue. Expand
A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis
TLDR
It is concluded that this regulator, designated elsewhere as kstR, controls the expression of genes used for utilizing diverse lipids as energy sources, possibly imported through the mce4 system. Expand
The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.
TLDR
An Emb-sensitive cell-free assay for arabinan biosynthesis shows that overexpression of embAB is associated with high-level Emb-resistant arabinosyl transferase activity, and that embR appears to modulate the in vitro level of this activity. Expand
Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean
TLDR
Human tuberculosis was confirmed by morphological and molecular methods in a population living in one of the first villages with evidence of agriculture and animal domestication and gave support to the theory of a long-term co-existence of host and pathogen. Expand
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response
TLDR
It is hypothesized that the LAM/LM ratio might be a crucial factor in determining the virulence of a mycobacterial species and the outcome of the infection. Expand
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