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tetrahydrodeoxycorticosterone

Known as: 3 alpha,5 beta-tetrahydrodeoxycorticosterone, THDOC, 3,21-dihydroxypregnan-20-one 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (4)

AnestheticsAnti-Anxiety AgentsNeurohormonesdesoxycorticosterone
Hypothalamic HormonesNeurosecretory Systemsanalogs & derivatives

Narrower (3)

Melatoninallotetrahydrodeoxycorticosteronetetrahydrodeoxycorticosterone, (3beta,5alpha)-isomer

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
The δ Subunit of γ-Aminobutyric Acid Type A Receptors Does Not Confer Sensitivity to Low Concentrations of Ethanol
GABAA receptors (GABAARs) are usually formed by α, β, and γ or δ subunits. Recently, δ-containing GABAARs expressed in Xenopus… 
Highly Cited
2002
Highly Cited
2002
Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABAA Receptor Function and Seizure Susceptibility
Stress affects seizure susceptibility in animals and humans, but the underlying mechanisms are obscure. Here, we provide evidence… 
Highly Cited
2002
Highly Cited
2002
Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors.
1: The pharmacology of the stable cell line expressing human alpha(4)beta(3)delta GABA(A) receptor was investigated using whole… 
Highly Cited
1997
Highly Cited
1997
Neurosteroid Prolongs GABAA Channel Deactivation by Altering Kinetics of Desensitized States
Fast applications of GABA (1 mm) to nucleated and outside-out patches excised from granule neurons in cerebellar slices from… 
Highly Cited
1996
Highly Cited
1996
δ Subunit Inhibits Neurosteroid Modulation of GABAAReceptors
Neurosteroid modulation of GABAA receptors has been observed with all subunit combinations investigated; however, hetero… 
Highly Cited
1994
Highly Cited
1994
Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats
Highly Cited
1993
Highly Cited
1993
Progesterone receptor-mediated effects of neuroactive steroids
Highly Cited
1990
Highly Cited
1990
Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites.
The potentiation of gamma-aminobutyric acid (GABA) receptor-mediated 36Cl- uptake by various steroids has been characterized in… 
Highly Cited
1986
Highly Cited
1986
Anxiolytic activity of an endogenous adrenal steroid
Highly Cited
1983
Highly Cited
1983
Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. A study of 25 patients.
Twenty five patients (10 males and 15 females) aged 0-23 yr with congenital adrenal hyperplasis due to 11 beta-hydroxylase… 
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