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RationaleNeurosteroids are steroids synthesized within the brain with rapid effects on neuronal excitability. Allopregnanolone… Expand This chapter provides an overview of neurosteroids, especially their impact on the brain, sex differences and their therapeutic… Expand Tonic GABAA receptor-mediated inhibition is typically generated byδ subunit-containing extrasynaptic receptors. Because the… Expand Many of the biological actions of progesterone are mediated through the progesterone receptor (PR), a nuclear transcription… Expand Stress affects seizure susceptibility in animals and humans, but the underlying mechanisms are obscure. Here, we provide evidence… Expand Summary: Purpose: Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone‐derived… Expand The discovery that the endogenous steroid derivatives 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone, or 3 alpha,5… Expand The effects of social isolation on behavior, neuroactive steroid concentrations, and GABAA receptor function were investigated in… Expand Alcohol administration (1 g/kg, i.p.) increased the levels of the neurosteroids 3alpha-hydroxy-5alpha-pregnan-20-one… Expand The relation between changes in brain and plasma concentrations of neurosteroids and the function and structure of gamma… Expand