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Sarcopenia with limited mobility: an international consensus.
TLDR
It is concluded that "Sarcopenia, ie, reduced muscle mass, with limited mobility" should be considered an important clinical entity and that most older persons should be screened for this condition. Expand
Management of Metabolic Complications Associated With Antiretroviral Therapy for HIV‐1 Infection: Recommendations of an International AIDS Society‐USA Panel
TLDR
These recommendations were developed to guide physicians actively involved in HIV care in the management of metabolic complications that occur primarily within the context of potent antiretroviral therapy. Expand
Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.
TLDR
Tissue-specific reductions in cholesterol esterification provide evidence that in mammals this process involves more than one form of esters enzyme, and will be useful in testing the role of ACAT and macrophage foam cell formation in atherosclerosis. Expand
Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel
TLDR
It is demonstrated that Liddle's syndrome is caused by mutations in the beta subunit of the epithelial sodium channel and have implications for the regulation of this epithelial ion channel as well as blood pressure homeostasis. Expand
Improvement in Peripheral Glucose Uptake After Gastric Bypass Surgery Is Observed Only After Substantial Weight Loss Has Occurred and Correlates with the Magnitude of Weight Lost
TLDR
Improvement in peripheral glucose uptake following RYGB was observed only after substantial weight loss had occurred and correlated with the magnitude of weight lost, and M values improved significantly, and changes in M values correlate with the % EWL. Expand
Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection.
TLDR
Changes in glucose and lipid metabolism are induced by PI therapy in the absence of significant changes in weight or fat distribution, and the risks associated with these metabolic effects do not appear to outweigh improvements in survival seen with PI therapy. Expand
Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional Ability
TLDR
A 6-month randomized, controlled, double-blind trial comparing recombinant human growth hormone therapy with placebo in 56 elderly men whose baseline insulin-like growth factor 1 levels were less than the tenth percentile found in younger healthy adults was conducted. Expand
The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia.
TLDR
Results from this pilot study suggest that leptin warrants further study in patients with HIV-associated lipoatrophy, and Leptin treatment was associated with marked improvement in dyslipidemia. Expand
Time- and exercise-dependent gene regulation in human skeletal muscle
TLDR
The coordinated regulation of the circadian clock genes Cry1, Per2, and Bmal1 6 Hours after RE and diurnal genes 18 hours after RE in the exercised leg suggest that RE may directly modulate circadian rhythms in human skeletal muscle. Expand
Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat.
TLDR
Short-term high-fructose intake was associated with increased DNL and liver fat in healthy men fed weight-maintaining diets, suggesting blunted suppression of EGP. Expand
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