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temsirolimus

Known as: 42-(3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin, 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin, temsirolimus [Chemical/Ingredient] 
An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
PURPOSE Recent data showed improvement in progression-free survival (PFS) when adding everolimus to exemestane in patients with… Expand
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Highly Cited
2011
Highly Cited
2011
PURPOSE Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene, and loss of function mutations are common and appear to… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE Despite high initial remission rates, most lymphomas relapse and require further therapy. The mammalian target of… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE Temsirolimus, a specific inhibitor of the mammalian target of rapamycin kinase, has shown clinical activity in mantle… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Interferon alfa is widely used for metastatic renal-cell carcinoma but has limited efficacy and tolerability… Expand
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Highly Cited
2006
Highly Cited
2006
Mammalian target of rapamycin (mTOR) is increasingly recognized as a master regulator of fundamental cellular functions, whose… Expand
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Highly Cited
2006
Highly Cited
2006
Standard cytotoxic treatments for neuroendocrine tumours have been associated with limited activity and remarkable toxicity. A… Expand
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Highly Cited
2005
Highly Cited
2005
PURPOSE Mantle cell lymphoma (MCL) is characterized by a t(11;14) resulting in overexpression of cyclin D1 messenger RNA. This… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Temsirolimus (CCI-779) is a small-molecule inhibitor of the mammalian target of rapamycin (mTOR) and represents a… Expand
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Highly Cited
2005
Highly Cited
2005
PURPOSE In this study, two doses of temsirolimus (CCI-779), a novel inhibitor of the mammalian target of rapamycin, were… Expand
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