temsirolimus

Known as: 42-(3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin, 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin, temsirolimus [Chemical/Ingredient] 
An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2018
05010015019742018

Papers overview

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Highly Cited
2013
Highly Cited
2013
PURPOSE Recent data showed improvement in progression-free survival (PFS) when adding everolimus to exemestane in patients with… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene, and loss of function mutations are common and appear to… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Temsirolimus, a specific inhibitor of the mammalian target of rapamycin kinase, has shown clinical activity in mantle… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Temsirolimus, a novel inhibitor of mammalian target of rapamycin, has demonstrated prolonged overall survival and… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Interferon alfa is widely used for metastatic renal-cell carcinoma but has limited efficacy and tolerability… (More)
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Highly Cited
2006
Highly Cited
2006
Mammalian target of rapamycin (mTOR) is increasingly recognized as a master regulator of fundamental cellular functions, whose… (More)
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Highly Cited
2006
Highly Cited
2006
Standard cytotoxic treatments for neuroendocrine tumours have been associated with limited activity and remarkable toxicity. A… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Temsirolimus (CCI-779) is a small-molecule inhibitor of the mammalian target of rapamycin (mTOR) and represents a… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE Mantle cell lymphoma (MCL) is characterized by a t(11;14) resulting in overexpression of cyclin D1 messenger RNA. This… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE In this study, two doses of temsirolimus (CCI-779), a novel inhibitor of the mammalian target of rapamycin, were… (More)
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