CCI 779

Known as: Rapamycin Analog CCI-779, Cell Cycle Inhibitor 779, CCI-779 
 
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
BACKGROUND Temsirolimus (CCI-779) is a small-molecule inhibitor of the mammalian target of rapamycin (mTOR) and represents a… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE Mantle cell lymphoma (MCL) is characterized by a t(11;14) resulting in overexpression of cyclin D1 messenger RNA. This… (More)
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Highly Cited
2005
Highly Cited
2005
Purpose: Loss of PTEN, which is common in glioblastoma multiforme (GBM), results in activation of the mammalian target of… (More)
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Highly Cited
2005
Highly Cited
2005
Tuberous sclerosis complex (TSC) is a familial tumor disorder for which there is no effective medical therapy. Disease-causing… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE In this study, two doses of temsirolimus (CCI-779), a novel inhibitor of the mammalian target of rapamycin, were… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE To establish the safety, tolerability, and pharmacokinetic parameters of CCI-779, a selective inhibitor of the mammalian… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE To evaluate the efficacy, safety, and pharmacokinetics of multiple doses of CCI-779, a novel mammalian target of… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND CCI-779 is an analog of the immunosuppressive agent, rapamycin, that has demonstrated activity against melanoma in… (More)
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Highly Cited
2002
Highly Cited
2002
Recent work identifies the AKT kinase as a potential mediator of tumor expansion in multiple myeloma. The finding of PTEN… (More)
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Highly Cited
2001
Highly Cited
2001
The rapamycin ester, CCI-779, potently inhibits cell growth in vitro, inhibits tumor growth in vivo, and is currently in Phase I… (More)
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