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CCI 779

Known as: Rapamycin Analog CCI-779, Cell Cycle Inhibitor 779, CCI-779 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

temsirolimus

Papers overview

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2014
2014
The Rapalogue, CCI-779, Improves Salivary Gland Function following Radiation
The standard of care for head and neck cancer typically includes surgical resection of the tumor followed by targeted head and… 
2014
2014
Real-time monitoring of changes in brain extracellular sodium and potassium concentrations and intracranial pressure after selective vasopressin-1a receptor inhibition following focal traumatic brain…
Brain swelling and increased intracranial pressure (ICP) following traumatic brain injury (TBI) contribute to poor outcome… 
2013
2013
The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells
BackgroundLiver cancer is one of the most frequent cancers in the world. Targeted therapy of cancer with specific inhibitors is… 
Highly Cited
2011
Highly Cited
2011
A phase 2 study of temsirolimus (CCI‐779) in patients with soft tissue sarcomas
The primary goal of this trial was to evaluate the confirmed response rate of temsirolimus (CCI‐779), a mammalian target of… 
2011
2011
Delayed sodium pyruvate treatment improves working memory following experimental traumatic brain injury
2010
2010
Descending serotonergic facilitation mediated by spinal 5-HT3 receptors engages spinal rapamycin-sensitive pathways in the rat
2007
2007
CCI-779 plus Cisplatin Is Highly Effective against Human Melanoma in a SCID Mouse Xenotranplantation Model
Background: This study set out to investigate the antitumor effects of a treatment strategy combining the mTOR inhibitor CCI-779… 
Review
2004
Review
2004
Molecular targeting therapy for pancreatic cancer
Pancreatic carcinogenesis is driven by multiple genetic and epigenetic changes. The epidermal growth factor receptor (EGFR) and… 
2003
2003
Insulin-like Growth Factor Binding Protein-6 and CCI-779, an Ester Analogue of Rapamycin, Additively Inhibit Rhabdomyosarcoma Growth
in vitro in vitro v in vitro in vivo. 
Highly Cited
2001
Highly Cited
2001
Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
Molecular therapeutics, targeting the underlying defects leading to cancer initiation and progression, are the “holy grail” of… 
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