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Sirolimus

Known as: RAPAMYCIN, RAPA, SLM 
A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Regulatory T cells (Tregs) are important for the induction and maintenance of peripheral tolerance therefore, they are key in… Expand
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Review
2019
Review
2019
Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important… Expand
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Review
2019
Review
2019
ABSTRACT Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria. Accumulating… Expand
Review
2019
Review
2019
Long known as terminal degradation stations, lysosomes have emerged as sophisticated signalling centres that govern cell growth… Expand
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Review
2019
Review
2019
The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally known as mammalian target of rapamycin) is… Expand
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Review
2019
Review
2019
Autophagy is a preserved cytoplasmic self‐degradation process and endorses recycling of intracellular constituents into… Expand
Review
2019
Review
2019
One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that occurs in response to resistance… Expand
Review
2018
Review
2018
Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus… Expand
Review
2018
Review
2018
This review offers a systematic understanding about how polyphenols target multiple inflammatory components and lead to anti… Expand
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Review
2018
Review
2018
The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular growth and metabolism with environmental inputs to… Expand
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