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Sirolimus

Known as: RAPAMYCIN, RAPA, SLM 
A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to… 
National Institutes of Health

Papers overview

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Review
2012
Highly Cited
2012
Highly Cited
2012
BACKGROUND Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that… 
Highly Cited
2011
Highly Cited
2011
Autophagy is a process by which components of the cell are degraded to maintain essential activity and viability in response to… 
Highly Cited
2008
Highly Cited
2008
BACKGROUND Angiomyolipomas in patients with the tuberous sclerosis complex or sporadic lymphangioleiomyomatosis are associated… 
Highly Cited
2007
Highly Cited
2007
BACKGROUND The safety of drug-eluting stents has been called into question by recent reports of increased stent thrombosis… 
Review
2006
Highly Cited
2005
Highly Cited
2005
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires… 
Review
2004
Review
2004
The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth… 
Highly Cited
2003
Highly Cited
2003
BACKGROUND Preliminary reports of studies involving simple coronary lesions indicate that a sirolimus-eluting stent significantly… 
Highly Cited
2002
Highly Cited
2002
BACKGROUND The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary…