Sirolimus

Known as: RAPA, Rapamycin, SLM 
A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to… (More)

Topic mentions per year

Topic mentions per year

1970-2017
010002000300019702017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Tuberous sclerosis complex (TSC) is a multisystem disorder that results from heterozygous mutations in either TSC1 or TSC2. The… (More)
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Review
2016
Review
2016
Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute… (More)
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Review
2016
Review
2016
Mutation of the KRAS oncogene in pancreatic cancer is responsible for permanent activation of the P21 RAS protein and the cascade… (More)
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Review
2016
Review
2016
Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The safety of drug-eluting stents has been called into question by recent reports of increased stent thrombosis… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Stent thrombosis is a safety concern associated with use of drug-eluting stents. Little is known about occurrence of… (More)
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Highly Cited
2005
Highly Cited
2005
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND The US Food and Drug Administration recently issued a warning of subacute thrombosis and hypersensitivity reactions to… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Preliminary reports of studies involving simple coronary lesions indicate that a sirolimus-eluting stent significantly… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary… (More)
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