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Sirolimus

Known as: RAPAMYCIN, RAPA, SLM 
A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein… Expand
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Review
2018
Review
2018
PurposeTriple-negative breast cancer (TNBC) accounts for approximately 20% of breast cancer cases. Although there have been… Expand
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Review
2018
Review
2018
In the last two decades, accumulating evidence pointed to the importance of autophagy in various human diseases. As an essential… Expand
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Review
2018
Review
2018
Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative anesthetic ketamine induces rapid and… Expand
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Review
2018
Review
2018
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues… Expand
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Review
2018
Review
2018
Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading and recycling cellular constituents, and for… Expand
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Review
2017
Review
2017
Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic… Expand
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Review
2017
Review
2017
Cells and organisms must coordinate their metabolic activity with changes in their environment to ensure their growth only when… Expand
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Review
2017
Review
2017
The mechanistic target of rapamycin (mTOR) network is an evolutionary conserved signaling hub that senses and integrates… Expand
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Review
2017
Review
2017
HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately linked to epithelial… Expand
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