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Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy
Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genesExpand
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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. The roles of two signalling pathways implicated in muscle hypertrophy on the basis of findings inExpand
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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.
Skeletal muscle size depends upon a dynamic balance between anabolic (or hypertrophic) and catabolic (or atrophic) processes. Previously, no link between the molecular mediators of atrophy andExpand
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Skeletal muscle hypertrophy and atrophy signaling pathways.
  • D. Glass
  • Biology, Medicine
  • The international journal of biochemistry & cell…
  • 1 October 2005
Skeletal muscle hypertrophy is defined as an increase in muscle mass, which in the adult animal comes as a result of an increase in the size, as opposed to the number, of pre-existing skeletal muscleExpand
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IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.
Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and immobilization. We show that activation of NF-kappaB, throughExpand
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The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo
Formation of neuromuscular synapses requires a series of inductive interactions between growing motor axons and differentiating muscle cells, culminating in the precise juxtaposition of a highlyExpand
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IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and immobilization. We show that activation of NF-kappaB, throughExpand
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Agrin Acts via a MuSK Receptor Complex
Formation of th neuromuscular junction depends upon reciprocal inductive interactions between the developing nerve and muscle, resulting in the precise juxtaposition of a differentiated nerveExpand
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Cancer cachexia: mediators, signaling, and metabolic pathways.
Cancer cachexia is characterized by a significant reduction in body weight resulting predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced cancer treatment toleranceExpand
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Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.
Extracellular signals often result in simultaneous activation of both the Raf-MEK-ERK and PI3K-Akt pathways (where ERK is extracellular-regulated kinase, MEK is mitogen-activated protein kinase orExpand
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