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tedizolid phosphate

Known as: Torezolid Phosphate, [(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (4)

Anti-Bacterial AgentsOrganophosphatesOxazolestedizolid
Bacterial InfectionsBreast Cancer Resistance Protein Inhibitors [MoA]Oxazolidinonestedizolid phosphate 200 MG Oral Tablet

Narrower (3)

DA 7218SivextroTR 701

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Single- and Multiple-Dose Pharmacokinetics and Absolute Bioavailability of Tedizolid
Tedizolid phosphate is a novel antibacterial under investigation for the treatment of gram‐positive infections. This study was… 
Highly Cited
2014
Highly Cited
2014
Absorption, Distribution, Metabolism, and Excretion of the Novel Antibacterial Prodrug Tedizolid Phosphate
Tedizolid phosphate is a novel antibacterial prodrug with potent activity against Gram-positive pathogens. In vitro and in vivo… 
Review
2014
Review
2014
Use of pharmacokinetic/pharmacodynamic systems analyses to inform dose selection of tedizolid phosphate.
In the Staphylococcus aureus neutropenic murine thigh-infection model, the ratio of the free area under the 24-hour concentration… 
Review
2014
Review
2014
Tedizolid phosphate for the management of acute bacterial skin and skin structure infections: safety summary.
The novel oxazolidinone tedizolid phosphate is in late-stage clinical development. In an effort to improve efficacy and safety… 
Review
2012
Review
2012
Improving known classes of antibiotics: an optimistic approach for the future.
  • K. Bush
  • Current opinion in pharmacology (Print)
  • 2012
  • Corpus ID: 36345077
Highly Cited
2012
Highly Cited
2012
Comparative In Vivo Efficacies of Epithelial Lining Fluid Exposures of Tedizolid, Linezolid, and Vancomycin for Methicillin-Resistant Staphylococcus aureus in a Mouse Pneumonia Model
ABSTRACT The antibacterial efficacies of tedizolid phosphate (TZD), linezolid, and vancomycin regimens simulating human exposures… 
Review
2012
Review
2012
Tedizolid (TR-701): a new oxazolidinone with enhanced potency
Introduction: Tedizolid phosphate (TR-701) is a new oxazolidinone prodrug that is transformed in the serum into the active drug… 
Highly Cited
2012
Highly Cited
2012
Comparative Pharmacodynamics of the New Oxazolidinone Tedizolid Phosphate and Linezolid in a Neutropenic Murine Staphylococcus aureus Pneumonia Model
ABSTRACT Tedizolid phosphate (TR-701) is a novel oxazolidinone prodrug (converted to the active form tedizolid [TR-700]) with… 
2012
2012
Activity of Tedizolid Phosphate (TR-701) in Murine Models of Infection with Penicillin-Resistant and Penicillin-Sensitive Streptococcus pneumoniae
ABSTRACT The in vitro activity of tedizolid (previously known as torezolid, TR-700) against penicillin-resistant Streptococcus… 
Review
2011
Review
2011
The oxazolidinones: past, present, and future
The success of linezolid stimulated significant efforts to discover new agents in the oxazolidinone class. Over a dozen… 
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