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Aminoglycosides: Activity and Resistance
- M. Mingeot-Leclercq, Y. Glupczynski, P. Tulkens
- ChemistryAntimicrobial Agents and Chemotherapy
- 1 April 1999
Aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable properties for the treatment of life-threatening infections and have a history marked by the successive introduction of a series of milestone compounds.
Effect of a Collaborative Approach on the Quality of Prescribing for Geriatric Inpatients: A Randomized, Controlled Trial
- A. Spinewine, C. Swine, P. Tulkens
- Medicine, Political ScienceJournal of The American Geriatrics Society
- 1 May 2007
OBJECTIVES: To evaluate the effect of pharmaceutical care provided in addition to acute Geriatric Evaluation and Management (GEM) care on the appropriateness of prescribing.
The present minireview tries to present in a prospective way the status of both the basic and the clinical research on aminoglycoside nephrotoxicity in order to clarify the main issues and to pinpoint strategies that may eventually lead to their safer use.
Pharmacodynamic Evaluation of the Intracellular Activities of Antibiotics against Staphylococcus aureus in a Model of THP-1 Macrophages
- M. Barcia-Macay, C. Seral, M. Mingeot-Leclercq, P. Tulkens, F. Van Bambeke
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 March 2006
The intracellular activities of antibiotics against S. aureus are critically dependent upon their extracellular concentrations and the duration of cell exposure (within the 0- to 24-h time frame) to antibiotics and are always lower than those that can be observedextracellularly.
Hepatic safety of antibiotics used in primary care
Patients at risk are mainly those with previous experience of hepatotoxic reaction to antibiotics, the aged or those with impaired hepatic function in the absence of close monitoring, making it important to carefully balance potential risks with expected benefits in primary care.
Implementation of Ward-Based Clinical Pharmacy Services in Belgium—Description of the Impact on a Geriatric Unit
- A. Spinewine, S. Dhillon, L. Mallet, P. Tulkens, L. Wilmotte, C. Swine
- MedicineThe Annals of pharmacotherapy
- 1 April 2006
Involving a trained clinical pharmacist in a geriatric team led to clinically relevant and well-accepted optimization of medicine use and this initiative may be a springboard for further development of clinical pharmacy services.
Climate evolution during the Holocene: a study with an Earth system model of intermediate complexity
- M. Crucifix, M. Loutre, P. Tulkens, T. Fichefet, A. Berger
- Environmental Science, Geography
- 1 May 2002
Abstract.An Earth system model of intermediate complexity, MoBidiC, has been used to simulate the transient variations in continental temperature, sea-surface temperature (SST), thermohaline…
A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa.
- N. Mesaros, Y. Glupczynski, L. Avrain, N. E. Caceres, P. Tulkens, F. Van Bambeke
- Biology, MedicineJournal of Antimicrobial Chemotherapy
- 1 March 2007
The data plead for combining phenotypic and genotypic approaches in the diagnosis of efflux-mediated resistance in P. aeruginosa.
Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections.
- F. Van Bambeke, J. Harms, Y. Van Laethem, P. Tulkens
- Biology, MedicineExpert opinion on pharmacotherapy
Telithromycin indications have been recently restricted by the US FDA to community-acquired pneumonia, and caution in patients at risk has been advocated by the European authorities, calling for continuous and careful surveys of bacterial susceptibility.