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Experience with a once-daily aminoglycoside program administered to 2,184 adult patients.
Once-daily aminoglycoside (ODA) regimens have been instituted to maximize bacterial killing by optimizing the peak concentration/MIC ratio and to reduce the potential for toxicity. We initiated anExpand
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Randomized, Open-Label, Comparative Study of Piperacillin-Tazobactam Administered by Continuous Infusion versus Intermittent Infusion for Treatment of Hospitalized Patients with Complicated
ABSTRACT The purpose of this randomized, multicenter, open-label study was to compare the continuous infusion of piperacillin-tazobactam with the standard intermittent infusion in 262 hospitalizedExpand
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Double-Carbapenem Therapy for Carbapenemase-Producing Klebsiella pneumoniae
ABSTRACT The limited treatment options available for carbapenemase-producing Klebsiella pneumoniae (KPC) have made it a formidable pathogen. Previously we have shown the enhanced activity ofExpand
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Continuous versus intermittent administration of ceftazidime in intensive care unit patients with nosocomial pneumonia.
A prospective, randomized pilot study was undertaken to compare the efficacy of continuous versus intermittent ceftazidime in ICU patients with nosocomial pneumonia. Ceftazidime was administeredExpand
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The pharmacodynamics of aminoglycosides.
Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidalExpand
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Clinical Pharmacodynamics of Meropenem in Patients with Lower Respiratory Tract Infections
ABSTRACT Studies of β-lactam pharmacodynamics in infected patients are sparse. In this study, classification and regression tree (CART) and logistic regression analyses were used to identify whichExpand
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Steady-state intrapulmonary concentrations of moxifloxacin, levofloxacin, and azithromycin in older adults.
STUDY OBJECTIVE To determine the steady-state, extracellular, and intracellular pulmonary disposition of moxifloxacin (MXF), levofloxacin (LEVO), and azithromycin (AZI) relative to that of the plasmaExpand
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Impact of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species on clinical outcomes and hospital costs: a matched cohort study.
OBJECTIVES To evaluate the economic and clinical impact of infection with extended-spectrum beta -lactamase (ESBL)-producing Escherichia coli and Klebsiella species (ESBL-EK). DESIGN AExpand
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Population Pharmacokinetic Analysis and Dosing Regimen Optimization of Meropenem in Adult Patients
The objectives of this study were to develop a meropenem population pharmacokinetic model using patient data and use it to explore alternative dosage regimens that could optimize the currently usedExpand
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Pharmacokinetics of Intravenous Linezolid in Moderately to Morbidly Obese Adults
ABSTRACT The pharmacokinetics of linezolid was assessed in 20 adult volunteers with body mass indices (BMI) of 30 to 54.9 kg/m2 receiving 5 intravenous doses of 600 mg every 12 h. PharmacokineticExpand
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