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tedisamil

Known as: 3,7-di-(cyclopropylmethyl)-9,9-tetramethylene-3,7-diazabicyclo(3.3.1)nonane 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Anti-Arrhythmia AgentsBridged Bicyclo Compounds, HeterocyclicCardiotonic AgentsCyclopropanes

Narrower (1)

KC 8857
Tedisamil Sesquifumarate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
New horizons in antiarrhythmic therapy: will novel agents overcome current deficits?
Review
2008
Review
2008
Relationship among amiodarone, new class III antiarrhythmics, miscellaneous agents and acquired long QT syndrome.
Class III drugs prolong the QT interval by blocking mainly the delayed rectifier rapid potassium outward current (IKr), with… 
Review
2001
Review
2001
Tedisamil: master switch of nature?
Decreasing heart rate is potentially useful in ischaemic heart disease. Tedisamil is a bradycardic agent resulting from its… 
2000
2000
Antianginal and anti-ischaemic efficacy of tedisamil, a potassium channel blocker
OBJECTIVE To determine the efficacy and safety of the potassium channel blocker tedisamil versus placebo in the treatment of… 
1998
1998
Comparative effects of glibenclamide, tedisamil, dofetilide, E-4031, and BRL-32872 on protein kinase A-activated chloride current in guinea pig ventricular myocytes.
The modulation of the protein kinase A-activated chloride current (PKA-I[Cl]) may lead to modification of the cardiac action… 
1998
1998
Antifibrillatory efficacy of long-term tedisamil administration in a postinfarcted canine model of ischemic ventricular fibrillation.
The electrophysiologic and antifibrillatory properties of tedisamil (KC-8857) were studied in vivo in a conscious canine model of… 
Review
1997
Review
1997
Emerging Class III Antiarrhythmic Agents:Mechanism of Action and Proarrhythmic Potential
The goal of developing an antiarrhythmic agent effective against malignant ventricular arrhythmias while maintaining a low side… 
1996
1996
Effects of tedisamil (KC‐8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart
1 The direct cardiac electrophysiological and antifibrillatory actions of tedisamil (KC‐8857) were studied in rabbit isolated… 
Review
1994
Review
1994
ION CHANNEL MODULATORS AS POTENTIAL POSITIVE INOTROPIC COMPOUNDS FOR TREATMENT OF HEART FAILURE
1. Current positive inotropy therapy of heart failure is associated with major problems: digoxin and the phosphodiesterase… 
Highly Cited
1991
Highly Cited
1991
Influence of Tedisamil on the Initiation and Maintenance of Ventricular Fibrillation: Chemical Defibrillation by Ito Blockade?
We examined the effects of tedisamil on ventricular fibrillation (VF) elicited by regional ischemia and by reperfusion in… 
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