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tedisamil

Known as: 3,7-di-(cyclopropylmethyl)-9,9-tetramethylene-3,7-diazabicyclo(3.3.1)nonane 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Anti-Arrhythmia AgentsBridged Bicyclo Compounds, HeterocyclicCardiotonic AgentsCyclopropanes

Narrower (1)

KC 8857
Tedisamil Sesquifumarate

Papers overview

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2001
2001
Tedisamil and dofetilide‐induced torsades de pointes, rate and potassium dependence
Tedisamil is a bradycardiac agent that prolongs the QT interval of the ECG and prevents cardiac arrhythmias. Given this profile… 
Review
1998
Review
1998
Antiarrhythmic drugs: a reorientation in light of recent developments in the control of disorders of rhythm.
1998
1998
Mechanism of block by tedisamil of transient outward current in human ventricular subepicardial myocytes
1 Tedisamil is a new antiarrhythmic drug with predominant class III action. The aim of the present study was to investigate the… 
Review
1997
Review
1997
Emerging Class III Antiarrhythmic Agents:Mechanism of Action and Proarrhythmic Potential
The goal of developing an antiarrhythmic agent effective against malignant ventricular arrhythmias while maintaining a low side… 
1995
1995
Cardiac electrophysiologic and antiarrhythmic actions of tedisamil.
The Class III electrophysiologic and antiarrhythmic actions of the bradycardic agent tedisamil were assessed in vitro and in vivo… 
1994
1994
Effects of E-4031, almokalant and tedisamil on postrest action potential duration of human papillary muscles.
The new antiarrhythmic compounds E-4031 (1-[2-(6-methyl-2-pyridyl)ethyl]-4-(4-methylsulfonyl- aminobenzoyl)piperidine… 
Highly Cited
1991
Highly Cited
1991
Influence of Tedisamil on the Initiation and Maintenance of Ventricular Fibrillation: Chemical Defibrillation by Ito Blockade?
We examined the effects of tedisamil on ventricular fibrillation (VF) elicited by regional ischemia and by reperfusion in… 
Highly Cited
1991
Highly Cited
1991
Antiarrhythmic properties of tedisamil (KC8857), a putative transient outward K+ current blocker
1 Rats were used to evaluate the antiarrhythmic properties of tedisamil, a novel agent with the electrophysiological properties… 
Highly Cited
1990
Highly Cited
1990
Tedisamil blocks the transient and delayed rectifier K+ currents in mammalian cardiac and glial cells.
The potassium currents in rat and guinea pig ventricular myocytes and mouse astrocytes were studied using tedisamil, a novel… 
Highly Cited
1989
Highly Cited
1989
Tedisamil inactivates transient outward K+ current in rat ventricular myocytes.
The action of tedisamil, a new bradycardiac agent with antiarrhythmic properties, was investigated in single rat ventricular… 
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