• Publications
  • Influence
Mechanisms of myocardial reperfusion injury.
Reperfusion of the ischemic myocardium results in irreversible tissue injury and cell necrosis, leading to decreased cardiac performance. While early reperfusion of the heart is essential inExpand
  • 339
  • 15
Canine Myocardial Reperfusion Injury: Its Reduction by the Combined Administration of Superoxide Dismutase and Catalase
Therapy directed against the toxic effects of reactive oxygen species may reduce the final extent of ischemic injury in otherwise viable tissue irreversibly injured by the abrupt reoxygenation ofExpand
  • 940
  • 12
  • PDF
Reduction of the Extent of Ischemic Myocardial Injury by Neutrophil Depletion in the Dog
Accumulation of polymorphonuclear neutrophils during the acute inflammatory response may exacerbate tissue injury through the release of activated oxygen products or proteolytic enzymes or both. ToExpand
  • 1,195
  • 9
Activation of estrogen receptor-alpha protects the in vivo rabbit heart from ischemia-reperfusion injury.
The estrogen receptor (ER) mediates estrogenic activity in a variety of organs, including those in the reproductive, cardiovascular, immune, and central nervous systems. Experimental studies haveExpand
  • 136
  • 8
  • PDF
Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1
Pain associated with inflammation involves prostaglandins synthesized from arachidonic acid (AA) through cyclooxygenase-2 (COX-2) pathways while thromboxane A2 formed by platelets from AA viaExpand
  • 132
  • 7
  • PDF
Myocardial protection with preconditioning.
Myocardial preconditioning with brief coronary artery occlusions before a sustained ischemic period is reported to reduce infarct size. To determine the number of occlusive episodes required toExpand
  • 468
  • 6
  • PDF
Cardiac Actions of Glucagon
  • B. Lucchesi
  • Chemistry, Medicine
  • Circulation research
  • 1 June 1968
Glucagon increased heart rate and contractile force in the anesthetized dog and increased isometric tension in the isolated dog papillary muscle. The positive inotropic and chronotropic responsesExpand
  • 184
  • 6
  • PDF
Sulodexide: a renewed interest in this glycosaminoglycan.
Glycosaminoglycans (GAGs) are the most abundant group of heteropolysaccharides found in the body. These long unbranched molecules contain a repeating disaccharide unit. GAGs are located primarily inExpand
  • 56
  • 5
Modulation of leukocyte-mediated myocardial reperfusion injury.
  • 219
  • 4
The role of nicotine as a determinant of cigarette smoking frequency in man with observations of certain cardiovascular effects associated with the tobacco alkaloid
The effect of intravenously administered nicotine upon smoking behavior was studied in smokers who were unaware of the nature of the administered drug and the true purpose of the study. SmokingExpand
  • 147
  • 4