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taxadiene

National Institutes of Health

Papers overview

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Review
2018
Review
2018
In Vivo Platforms for Terpenoid Overproduction and the Generation of Chemical Diversity.
2017
2017
Taxus Cell Cultures , an Effective Biotechnological Tool to Enhance and Gain New Biosynthetic Insights into Taxane Production
Mass phytochemical production in biotechnological platforms based on plant cell and organ cultures provides an alternative to the… 
Highly Cited
2011
Highly Cited
2011
Analysis of heterologous taxadiene production in K- and B-derived Escherichia coli
Taxa-4(5),11(12)-diene is the first dedicated intermediate in the metabolic pathway responsible for synthesizing the anticancer… 
2011
2011
Biotransformation of a taxadiene by ginkgo cell cultures and the tumor multi-drug resistant reversal activities of the metabolites.
The biotransformation of 2α,5α,10β-triacetoxy-14-oxo-taxa-4(20),11-diene (1) by cultured Gingko cells afforded four products… 
2010
2010
Cloning of taxadiene synthase gene into Arabidopsis thaliana (ecotype Columbia-0).
Paclitaxel (Taxol), a complex diterpenoid, produced by yew tree (Taxus sp.) is the most important chemotherapeutic agent that is… 
2008
2008
Relationship of Viability and Apoptosis to Taxol Production in Taxus sp. Suspension Cultures Elicited with Methyl Jasmonate
Taxus cuspidata P991 in plant cell suspension culture is capable of producing the important anticancer agent Taxol (paclitaxel… 
2007
2007
A promiscuous proton in taxadiene biosynthesis?
Herein we describe quantum chemical calculations on a two-step proton-transfer pathway that interconverts key intermediates in… 
2005
2005
Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling.
Taxadiene synthase catalyzes the cyclization of (E,E,E)-geranylgeranyl diphosphate (GGPP) to taxa-4(5),11(12)-diene (Scheme 1, 5… 
2002
2002
cDNA cloning,expression and characterization of taxadiene synthase,a diterpene cyclase from taxus chinensis
Taxadiene synthase, a diterpene cyclase, catalyzes the conversion of geranylgeranyl diphosphate (GGPP) to taxadiene, a key… 
Highly Cited
1998
Highly Cited
1998
Overproduction, in Escherichia coli, of soluble taxadiene synthase, a key enzyme in the Taxol biosynthetic pathway.
Taxadiene synthase catalyzes the conversion of the universal precursor of diterpenoids, geranylgeranyl diphosphate, to taxadiene… 
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