Plant terpenoid synthases: molecular biology and phylogenetic analysis.
- J. Bohlmann, G. Meyer-Gauen, R. Croteau
- BiologyProceedings of the National Academy of Sciences…
- 14 April 1998
This review focuses on the monoterpene, sesquiterpene, and diterpene synthases of plant origin that use the corresponding C10, C15, and C20 prenyl diphosphates as substrates to generate the enormous…
Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes.
- B. M. Lange, T. Rujan, W. Martin, R. Croteau
- BiologyProceedings of the National Academy of Sciences…
- 21 November 2000
The results suggest that lateral gene transfer between eubacteria subsequent to the origin of plastids has played a major role in the evolution of this pathway.
Terpenoid metabolism.
- D. J. Mcgarvey, R. Croteau
- ChemistryThe Plant Cell
- 1 July 1995
Because all terpenoids are produced by a common biosynthetic pathway, sophisticated control mechanisms must exist to ensure the production of appropriate levels of these often structurally complex compounds in the proper metabolic, developmental, and environmental context.
Cyclization Enzymes in the Biosynthesis of Monoterpenes, Sesquiterpenes, and Diterpenes
- E. Davis, R. Croteau
- Chemistry
- 2000
Terpene synthases catalyze the first committed steps in the biosynthesis of monoterpenes, sesquiterpenes, and diterpenes. An overview is presented of the enzymology and mechanism of these terpene…
Taxol Biosynthesis and Molecular Genetics
- R. Croteau, R. E. Ketchum, R. Long, Rüdiger Kaspera, M. Wildung
- Biology, ChemistryPhytochemistry Reviews
- 1 June 2006
Taxus suspension cells (induced for taxoid biosynthesis by methyl jasmonate) were used for feeding studies, as the foundation for cell-free enzymology and as the source of transcripts for cDNA library construction and a variety of cloning strategies.
Genomic organization of plant terpene synthases and molecular evolutionary implications.
- S. Trapp, R. Croteau
- Biology, Environmental ScienceGenetics
- 1 June 2001
A model presented for the evolutionary history of plant terpenoid synthases suggests that this superfamily of genes responsible for natural products biosynthesis derived from terpene synthase genes involved in primary metabolism by duplication and divergence in structural and functional specialization.
Monoterpene Synthases from Common Sage (Salvia officinalis)*
- M. Wise, T. Savage, E. Katahira, R. Croteau
- BiologyJournal of Biological Chemistry
- 12 June 1998
Deduced sequence analysis and size exclusion chromatography indicate that the recombinant bornyl diphosphate synthase is a homodimer, whereas the other two recombinant enzymes are monomeric, consistent with the size and subunit architecture of their native enzyme counterparts.
Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase
- Soheil S. Mahmoud, R. Croteau
- BiologyProceedings of the National Academy of Sciences…
- 26 June 2001
These experiments demonstrate that essential oil quantity and quality can be regulated by metabolic engineering and alteration of the committed step of the mevalonate-independent pathway for supply of terpenoid precursors improves flux through the pathway that leads to increased monoterpene production, and antisense manipulation of a selected downstream monoter pene biosynthetic step leads to improved oil composition.
A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway.
- B. M. Lange, M. Wildung, D. McCaskill, R. Croteau
- BiologyProceedings of the National Academy of Sciences…
- 3 March 1998
The cloning from peppermint and heterologous expression in Escherichia coli of 1-deoxy-D-xylulose-5-phosphate synthase appears to represent a novel class of highly conserved transketolases and likely plays a key role in the biosynthesis of plastid-derived isoprenoids essential for growth, development, and defense in plants.
Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae.
- Jinghong M DeJong, Yule Liu, R. Croteau
- BiologyBiotechnology and Bioengineering
- 5 February 2006
Genetic analysis showed that yeast isoprenoid precursors could be utilized in the reconstituted pathway because products accumulated from the first two engineered pathway steps (leading to the committed intermediate taxadiene); however, a pathway restriction was encountered at the first cytochrome P450 hydroxylation step.
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