R. Croteau

Publications382
h-index93
Citations27,113
Highly Influential Citations1,171
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Plant terpenoid synthases: molecular biology and phylogenetic analysis.
This review focuses on the monoterpene, sesquiterpene, and diterpene synthases of plant origin that use the corresponding C10, C15, and C20 prenyl diphosphates as substrates to generate the enormous…
Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes.
TLDR
The results suggest that lateral gene transfer between eubacteria subsequent to the origin of plastids has played a major role in the evolution of this pathway.
Terpenoid metabolism.
TLDR
Because all terpenoids are produced by a common biosynthetic pathway, sophisticated control mechanisms must exist to ensure the production of appropriate levels of these often structurally complex compounds in the proper metabolic, developmental, and environmental context.
Taxol Biosynthesis and Molecular Genetics
TLDR
Taxus suspension cells (induced for taxoid biosynthesis by methyl jasmonate) were used for feeding studies, as the foundation for cell-free enzymology and as the source of transcripts for cDNA library construction and a variety of cloning strategies.
Cyclization Enzymes in the Biosynthesis of Monoterpenes, Sesquiterpenes, and Diterpenes
Terpene synthases catalyze the first committed steps in the biosynthesis of monoterpenes, sesquiterpenes, and diterpenes. An overview is presented of the enzymology and mechanism of these terpene…
Genomic organization of plant terpene synthases and molecular evolutionary implications.
TLDR
A model presented for the evolutionary history of plant terpenoid synthases suggests that this superfamily of genes responsible for natural products biosynthesis derived from terpene synthase genes involved in primary metabolism by duplication and divergence in structural and functional specialization.
Monoterpene Synthases from Common Sage (Salvia officinalis)*
TLDR
Deduced sequence analysis and size exclusion chromatography indicate that the recombinant bornyl diphosphate synthase is a homodimer, whereas the other two recombinant enzymes are monomeric, consistent with the size and subunit architecture of their native enzyme counterparts.
Terpenoid-based defenses in conifers: cDNA cloning, characterization, and functional expression of wound-inducible (E)-alpha-bisabolene synthase from grand fir (Abies grandis).
TLDR
Results suggest that induced (E)-alpha-bisabolene biosynthesis constitutes part of a defense response targeted to insect herbivores, and possibly fungal pathogens, that is distinct from induced oleoresin monoterpene production.
Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae.
TLDR
Genetic analysis showed that yeast isoprenoid precursors could be utilized in the reconstituted pathway because products accumulated from the first two engineered pathway steps (leading to the committed intermediate taxadiene); however, a pathway restriction was encountered at the first cytochrome P450 hydroxylation step.
Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase
  • S. Mahmoud, R. Croteau
  • Biology, Medicine
    Proceedings of the National Academy of Sciences…
  • 26 June 2001
TLDR
These experiments demonstrate that essential oil quantity and quality can be regulated by metabolic engineering and alteration of the committed step of the mevalonate-independent pathway for supply of terpenoid precursors improves flux through the pathway that leads to increased monoterpene production, and antisense manipulation of a selected downstream monoter pene biosynthetic step leads to improved oil composition.
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